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Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of l-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker

A simple, three-step chemoenzymatic synthesis of l-threo-3-benzyloxyaspartate (l-TBOA), as well as l-TBOA derivatives with F, CF(3), and CH(3) substituents at the aromatic ring, starting from dimethyl acetylenedicarboxylate was investigated. These chiral amino acids, which are extremely difficult to...

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Detalles Bibliográficos
Autores principales:	de Villiers, Jandré, de Villiers, Marianne, Geertsema, Edzard M, Raj, Hans, Poelarends, Gerrit J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517298/ https://www.ncbi.nlm.nih.gov/pubmed/26251674 http://dx.doi.org/10.1002/cctc.201500318

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