HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins

BACKGROUND: Hijacking of the cullin-RING E3 ubiquitin ligase (CRL) machinery is a common mechanism employed by diverse groups of viruses for the efficient counteraction and degradation of host proteins. In particular, HIV-1 Vpu usurps the SCF(β-TrCP) E3 ubiquitin ligase complex to mark CD4 for degra...

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Detalles Bibliográficos
Autores principales: Ramirez, Peter W, DePaula-Silva, Ana Beatriz, Szaniawski, Matt, Barker, Edward, Bosque, Alberto, Planelles, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517359/
https://www.ncbi.nlm.nih.gov/pubmed/26215564
http://dx.doi.org/10.1186/s12977-015-0192-2

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