Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma

BACKGROUND: An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In this study, we examined the effect of bevacizumab, a humanized monoclonal antibo...

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Detalles Bibliográficos
Autores principales: Chen, Ni, Ren, Meiping, Li, Rong, Deng, Xin, Li, Yongjie, Yan, Kai, Xiao, Lamei, Yang, Yan, Wang, Liqun, Luo, Mao, Fay, William P., Wu, Jianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517418/
https://www.ncbi.nlm.nih.gov/pubmed/26215730
http://dx.doi.org/10.1186/s12943-015-0418-x

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