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Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma
BACKGROUND: An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In this study, we examined the effect of bevacizumab, a humanized monoclonal antibo...
Autores principales: | Chen, Ni, Ren, Meiping, Li, Rong, Deng, Xin, Li, Yongjie, Yan, Kai, Xiao, Lamei, Yang, Yan, Wang, Liqun, Luo, Mao, Fay, William P., Wu, Jianbo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517418/ https://www.ncbi.nlm.nih.gov/pubmed/26215730 http://dx.doi.org/10.1186/s12943-015-0418-x |
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