Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo

Cancer cells secrete VEGF, which plays a key role in their growth, invasion, extravasation and metastasis. Direct cancer cell-endothelial cell interaction, mediated by gap junctions, is of critical importance in the extravasation process. In this study, we evaluated avastin (Av), an anti-VEGF antibo...

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Detalles Bibliográficos
Autores principales: Zibara, Kazem, Awada, Zahraa, Dib, Leila, El-Saghir, Jamal, Al-Ghadban, Sara, Ibrik, Aida, El-Zein, Nabil, El-Sabban, Marwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517444/
https://www.ncbi.nlm.nih.gov/pubmed/26218768
http://dx.doi.org/10.1038/srep12598

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