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Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders

Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesi...

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Autores principales: Naitou, Kiyotada, Shiina, Takahiko, Kato, Kurumi, Nakamori, Hiroyuki, Sano, Yuuki, Shimizu, Yasutake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517467/
https://www.ncbi.nlm.nih.gov/pubmed/26218221
http://dx.doi.org/10.1038/srep12623
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author Naitou, Kiyotada
Shiina, Takahiko
Kato, Kurumi
Nakamori, Hiroyuki
Sano, Yuuki
Shimizu, Yasutake
author_facet Naitou, Kiyotada
Shiina, Takahiko
Kato, Kurumi
Nakamori, Hiroyuki
Sano, Yuuki
Shimizu, Yasutake
author_sort Naitou, Kiyotada
collection PubMed
description Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesis that the descending noradrenergic pathway from the brain stem moderates gut motility, we examined effects of intrathecal application of noradrenaline to the spinal defecation center on colorectal motility. Colorectal intraluminal pressure and expelled volume were recorded in vivo in anesthetized rats. Intrathecal application of noradrenaline into the L6-S1 spinal cord, where the lumbosacral defecation center is located, caused propulsive contractions of the colorectum. Inactivation of spinal neurons by tetrodotoxin blocked the effect of noradrenaline. Pharmacological experiments showed that the effect of noradrenaline is mediated primarily by alpha-1 adrenoceptors. The enhancement of colorectal motility by intrathecal noradrenaline was abolished by severing of the pelvic nerves. Our results demonstrate that noradrenaline acting on sacral parasympathetic preganglionic neurons through alpha-1 adrenoceptors causes propulsive motility of the colorectum in rats. Considering that visceral pain activates the descending inhibitory pathways including noradrenergic neurons, our results provide a rational explanation of the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients.
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spelling pubmed-45174672015-07-30 Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders Naitou, Kiyotada Shiina, Takahiko Kato, Kurumi Nakamori, Hiroyuki Sano, Yuuki Shimizu, Yasutake Sci Rep Article Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesis that the descending noradrenergic pathway from the brain stem moderates gut motility, we examined effects of intrathecal application of noradrenaline to the spinal defecation center on colorectal motility. Colorectal intraluminal pressure and expelled volume were recorded in vivo in anesthetized rats. Intrathecal application of noradrenaline into the L6-S1 spinal cord, where the lumbosacral defecation center is located, caused propulsive contractions of the colorectum. Inactivation of spinal neurons by tetrodotoxin blocked the effect of noradrenaline. Pharmacological experiments showed that the effect of noradrenaline is mediated primarily by alpha-1 adrenoceptors. The enhancement of colorectal motility by intrathecal noradrenaline was abolished by severing of the pelvic nerves. Our results demonstrate that noradrenaline acting on sacral parasympathetic preganglionic neurons through alpha-1 adrenoceptors causes propulsive motility of the colorectum in rats. Considering that visceral pain activates the descending inhibitory pathways including noradrenergic neurons, our results provide a rational explanation of the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients. Nature Publishing Group 2015-07-28 /pmc/articles/PMC4517467/ /pubmed/26218221 http://dx.doi.org/10.1038/srep12623 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Naitou, Kiyotada
Shiina, Takahiko
Kato, Kurumi
Nakamori, Hiroyuki
Sano, Yuuki
Shimizu, Yasutake
Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
title Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
title_full Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
title_fullStr Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
title_full_unstemmed Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
title_short Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
title_sort colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517467/
https://www.ncbi.nlm.nih.gov/pubmed/26218221
http://dx.doi.org/10.1038/srep12623
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