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The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells

BACKGROUND: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood. METHODS: To...

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Detalles Bibliográficos
Autores principales:	Liefke, Robert, Windhof-Jaidhauser, Indra M., Gaedcke, Jochen, Salinas-Riester, Gabriela, Wu, Feizhen, Ghadimi, Michael, Dango, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517488/ https://www.ncbi.nlm.nih.gov/pubmed/26221185 http://dx.doi.org/10.1186/s13073-015-0180-0

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