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Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas

BACKGROUND: Recent developments in genomic sequencing have advanced our understanding of the mutations underlying human malignancy. Melanoma is a prototype of an aggressive, genetically heterogeneous cancer notorious for its biologic plasticity and predilection towards developing resistance to targe...

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Detalles Bibliográficos
Autores principales:	Lee, Jonathan J., Sholl, Lynette M., Lindeman, Neal I., Granter, Scott R., Laga, Alvaro C., Shivdasani, Priyanka, Chin, Gary, Luke, Jason J., Ott, Patrick A., Hodi, F. Stephen, Mihm, Martin C., Lin, Jennifer Y., Werchniak, Andrew E., Haynes, Harley A., Bailey, Nancy, Liu, Robert, Murphy, George F., Lian, Christine G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517542/ https://www.ncbi.nlm.nih.gov/pubmed/26221190 http://dx.doi.org/10.1186/s13148-015-0091-3

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