PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1

BACKGROUND: Pten plays a crucial role in the stem cell maintenance in a few organs. Pten defect also causes the premature oocytes and ovary aging. We and other groups have found that the phosphatidylinositol-3-OH kinase (PI3K)-Akt signaling regulates the proliferation and differentiation of spermato...

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Detalles Bibliográficos
Autores principales: Zhou, Wei, Shao, Hongfang, Zhang, Di, Dong, Jian, Cheng, Wei, Wang, Lu, Teng, Yincheng, Yu, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517568/
https://www.ncbi.nlm.nih.gov/pubmed/26221533
http://dx.doi.org/10.1186/s13578-015-0034-x

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