Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney

INTRODUCTION: Uncoupling protein 2 (UCP2) reduces production of reactive oxygen species (ROS) by mitochondria. ROS overproduction is one of the major contributors to the pathogenesis of chronic diabetic complications, such as diabetic kidney disease (DKD). Thus, deleterious polymorphisms in the UCP2...

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Detalles Bibliográficos
Autores principales: de Souza, Bianca Marmontel, Michels, Marcus, Sortica, Denise Alves, Bouças, Ana Paula, Rheinheimer, Jakeline, Buffon, Marjoriê Piuco, Bauer, Andrea Carla, Canani, Luís Henrique, Crispim, Daisy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517748/
https://www.ncbi.nlm.nih.gov/pubmed/26218518
http://dx.doi.org/10.1371/journal.pone.0132938

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