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Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates
Interleukin 17 (IL-17) is an important pro-inflammatory cytokine and plays critical roles in the immune response to pathogens and in the pathogenesis of inflammatory and autoimmune diseases. Despite its important functions, the origin and evolution of IL-17 in animal phyla have not been characterize...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517768/ https://www.ncbi.nlm.nih.gov/pubmed/26218896 http://dx.doi.org/10.1371/journal.pone.0132802 |
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author | Huang, Xian-De Zhang, Hua He, Mao-Xian |
author_facet | Huang, Xian-De Zhang, Hua He, Mao-Xian |
author_sort | Huang, Xian-De |
collection | PubMed |
description | Interleukin 17 (IL-17) is an important pro-inflammatory cytokine and plays critical roles in the immune response to pathogens and in the pathogenesis of inflammatory and autoimmune diseases. Despite its important functions, the origin and evolution of IL-17 in animal phyla have not been characterized. As determined in this study, the distribution of the IL-17 family among 10 invertebrate species and 7 vertebrate species suggests that the IL-17 gene may have originated from Nematoda but is absent from Saccoglossus kowalevskii (Hemichordata) and Insecta. Moreover, the gene number, protein length and domain number of IL-17 differ widely. A comparison of IL-17-containing domains and conserved motifs indicated somewhat low amino acid sequence similarity but high conservation at the motif level, although some motifs were lost in certain species. The third disulfide bond for the cystine knot fold is formed by two cysteine residues in invertebrates, but these have been replaced by two serine residues in Chordata and vertebrates. One third of invertebrate IL-17 proteins were found to have no predicted signal peptide. Furthermore, an analysis of phylogenetic trees and exon–intron structures indicated that the IL-17 family lacks conservation and displays high divergence. These results suggest that invertebrate IL-17 proteins have undergone complex differentiation and that their members may have developed novel functions during evolution. |
format | Online Article Text |
id | pubmed-4517768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45177682015-07-31 Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates Huang, Xian-De Zhang, Hua He, Mao-Xian PLoS One Research Article Interleukin 17 (IL-17) is an important pro-inflammatory cytokine and plays critical roles in the immune response to pathogens and in the pathogenesis of inflammatory and autoimmune diseases. Despite its important functions, the origin and evolution of IL-17 in animal phyla have not been characterized. As determined in this study, the distribution of the IL-17 family among 10 invertebrate species and 7 vertebrate species suggests that the IL-17 gene may have originated from Nematoda but is absent from Saccoglossus kowalevskii (Hemichordata) and Insecta. Moreover, the gene number, protein length and domain number of IL-17 differ widely. A comparison of IL-17-containing domains and conserved motifs indicated somewhat low amino acid sequence similarity but high conservation at the motif level, although some motifs were lost in certain species. The third disulfide bond for the cystine knot fold is formed by two cysteine residues in invertebrates, but these have been replaced by two serine residues in Chordata and vertebrates. One third of invertebrate IL-17 proteins were found to have no predicted signal peptide. Furthermore, an analysis of phylogenetic trees and exon–intron structures indicated that the IL-17 family lacks conservation and displays high divergence. These results suggest that invertebrate IL-17 proteins have undergone complex differentiation and that their members may have developed novel functions during evolution. Public Library of Science 2015-07-28 /pmc/articles/PMC4517768/ /pubmed/26218896 http://dx.doi.org/10.1371/journal.pone.0132802 Text en © 2015 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Huang, Xian-De Zhang, Hua He, Mao-Xian Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates |
title | Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates |
title_full | Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates |
title_fullStr | Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates |
title_full_unstemmed | Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates |
title_short | Comparative and Evolutionary Analysis of the Interleukin 17 Gene Family in Invertebrates |
title_sort | comparative and evolutionary analysis of the interleukin 17 gene family in invertebrates |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517768/ https://www.ncbi.nlm.nih.gov/pubmed/26218896 http://dx.doi.org/10.1371/journal.pone.0132802 |
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