Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense

[Image: see text] Investigation of a DCM extract of the bark of Pleiogynium timoriense from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC(50) value of 1.3 μg/mL against the A2780 ovarian cancer cell line. Bioassay-direc...

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Autores principales: Eaton, Alexander L., Rakotondraibe, L. Harinantenaina, Brodie, Peggy J., Goetz, Michael, Kingston, David G. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517783/
https://www.ncbi.nlm.nih.gov/pubmed/26132421
http://dx.doi.org/10.1021/acs.jnatprod.5b00119
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author Eaton, Alexander L.
Rakotondraibe, L. Harinantenaina
Brodie, Peggy J.
Goetz, Michael
Kingston, David G. I.
author_facet Eaton, Alexander L.
Rakotondraibe, L. Harinantenaina
Brodie, Peggy J.
Goetz, Michael
Kingston, David G. I.
author_sort Eaton, Alexander L.
collection PubMed
description [Image: see text] Investigation of a DCM extract of the bark of Pleiogynium timoriense from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC(50) value of 1.3 μg/mL against the A2780 ovarian cancer cell line. Bioassay-directed fractionation of this extract yielded the three new bioactive trihydroxyalkylcyclohexenones 1–3. Their structures were determined by a combination of spectroscopic and chemical methods. Compounds 1–3 exhibited submicromolar antiproliferative activity against the A2780 human ovarian cancer cell line, with IC(50) values of 0.8, 0.7, and 0.8 μM, respectively.
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spelling pubmed-45177832016-07-01 Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense Eaton, Alexander L. Rakotondraibe, L. Harinantenaina Brodie, Peggy J. Goetz, Michael Kingston, David G. I. J Nat Prod [Image: see text] Investigation of a DCM extract of the bark of Pleiogynium timoriense from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC(50) value of 1.3 μg/mL against the A2780 ovarian cancer cell line. Bioassay-directed fractionation of this extract yielded the three new bioactive trihydroxyalkylcyclohexenones 1–3. Their structures were determined by a combination of spectroscopic and chemical methods. Compounds 1–3 exhibited submicromolar antiproliferative activity against the A2780 human ovarian cancer cell line, with IC(50) values of 0.8, 0.7, and 0.8 μM, respectively. American Chemical Society and American Society of Pharmacognosy 2015-07-01 2015-07-24 /pmc/articles/PMC4517783/ /pubmed/26132421 http://dx.doi.org/10.1021/acs.jnatprod.5b00119 Text en Copyright © 2015 American Chemical Society and American Society of Pharmacognosy This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Eaton, Alexander L.
Rakotondraibe, L. Harinantenaina
Brodie, Peggy J.
Goetz, Michael
Kingston, David G. I.
Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense
title Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense
title_full Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense
title_fullStr Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense
title_full_unstemmed Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense
title_short Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense
title_sort antiproliferative trihydroxyalkylcyclohexenones from pleiogynium timoriense
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517783/
https://www.ncbi.nlm.nih.gov/pubmed/26132421
http://dx.doi.org/10.1021/acs.jnatprod.5b00119
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