Cargando…
Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography
Anterior segment optical coherent tomography (AS-OCT, Visante; Zeiss) is used to examine meridional variation in anterior scleral thickness (AST) and its association with refractive error, ethnicity and gender. Scleral cross-sections of 74 individuals (28 males; 46 females; aged between 18-40 years...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517791/ https://www.ncbi.nlm.nih.gov/pubmed/26218188 http://dx.doi.org/10.1371/journal.pone.0132902 |
_version_ | 1782383241560326144 |
---|---|
author | Buckhurst, Hetal D. Gilmartin, Bernard Cubbidge, Robert P. Logan, Nicola S |
author_facet | Buckhurst, Hetal D. Gilmartin, Bernard Cubbidge, Robert P. Logan, Nicola S |
author_sort | Buckhurst, Hetal D. |
collection | PubMed |
description | Anterior segment optical coherent tomography (AS-OCT, Visante; Zeiss) is used to examine meridional variation in anterior scleral thickness (AST) and its association with refractive error, ethnicity and gender. Scleral cross-sections of 74 individuals (28 males; 46 females; aged between 18-40 years (27.7±5.3)) were sampled twice in random order in 8 meridians: [superior (S), inferior (I), nasal (N), temporal (T), superior-temporal (ST), superior-nasal (SN), inferior-temporal (IT) and inferior-nasal (IN)]. AST was measured in 1mm anterior-to-posterior increments (designated the A-P distance) from the scleral spur (SS) over a 6mm distance. Axial length and refractive error were measured with a Zeiss IOLMaster biometer and an open-view binocular Shin-Nippon autorefractor. Intra- and inter-observer variability of AST was assessed for each of the 8 meridians. Mixed repeated measures ANOVAs tested meridional and A-P distance differences in AST with refractive error, gender and ethnicity. Only right eye data were analysed. AST (mean±SD) across all meridians and A-P distances was 725±46μm. Meridian SN was the thinnest (662±57μm) and I the thickest (806±60μm). Significant differences were found between all meridians (p<0.001), except S:ST, IT:IN, IT:N and IN:N. Significant differences between A-P distances were found except between SS and 6 mm and between 2 and 4 mm. AST measurements at 1mm (682±48 μm) were the thinnest and at 6mm (818±49 μm) the thickest (p<0.001); a significant interaction occurred between meridians and A-P distances (p<0.001). AST was significantly greater (p<0.001) in male subjects but no significant differences were found between refractive error or ethnicity. Significant variations in AST occur with regard to meridian and distance from the SS and may have utility in selecting optimum sites for pharmaceutical or surgical intervention. |
format | Online Article Text |
id | pubmed-4517791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45177912015-07-31 Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography Buckhurst, Hetal D. Gilmartin, Bernard Cubbidge, Robert P. Logan, Nicola S PLoS One Research Article Anterior segment optical coherent tomography (AS-OCT, Visante; Zeiss) is used to examine meridional variation in anterior scleral thickness (AST) and its association with refractive error, ethnicity and gender. Scleral cross-sections of 74 individuals (28 males; 46 females; aged between 18-40 years (27.7±5.3)) were sampled twice in random order in 8 meridians: [superior (S), inferior (I), nasal (N), temporal (T), superior-temporal (ST), superior-nasal (SN), inferior-temporal (IT) and inferior-nasal (IN)]. AST was measured in 1mm anterior-to-posterior increments (designated the A-P distance) from the scleral spur (SS) over a 6mm distance. Axial length and refractive error were measured with a Zeiss IOLMaster biometer and an open-view binocular Shin-Nippon autorefractor. Intra- and inter-observer variability of AST was assessed for each of the 8 meridians. Mixed repeated measures ANOVAs tested meridional and A-P distance differences in AST with refractive error, gender and ethnicity. Only right eye data were analysed. AST (mean±SD) across all meridians and A-P distances was 725±46μm. Meridian SN was the thinnest (662±57μm) and I the thickest (806±60μm). Significant differences were found between all meridians (p<0.001), except S:ST, IT:IN, IT:N and IN:N. Significant differences between A-P distances were found except between SS and 6 mm and between 2 and 4 mm. AST measurements at 1mm (682±48 μm) were the thinnest and at 6mm (818±49 μm) the thickest (p<0.001); a significant interaction occurred between meridians and A-P distances (p<0.001). AST was significantly greater (p<0.001) in male subjects but no significant differences were found between refractive error or ethnicity. Significant variations in AST occur with regard to meridian and distance from the SS and may have utility in selecting optimum sites for pharmaceutical or surgical intervention. Public Library of Science 2015-07-28 /pmc/articles/PMC4517791/ /pubmed/26218188 http://dx.doi.org/10.1371/journal.pone.0132902 Text en © 2015 Buckhurst et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Buckhurst, Hetal D. Gilmartin, Bernard Cubbidge, Robert P. Logan, Nicola S Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography |
title | Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography |
title_full | Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography |
title_fullStr | Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography |
title_full_unstemmed | Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography |
title_short | Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography |
title_sort | measurement of scleral thickness in humans using anterior segment optical coherent tomography |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517791/ https://www.ncbi.nlm.nih.gov/pubmed/26218188 http://dx.doi.org/10.1371/journal.pone.0132902 |
work_keys_str_mv | AT buckhursthetald measurementofscleralthicknessinhumansusinganteriorsegmentopticalcoherenttomography AT gilmartinbernard measurementofscleralthicknessinhumansusinganteriorsegmentopticalcoherenttomography AT cubbidgerobertp measurementofscleralthicknessinhumansusinganteriorsegmentopticalcoherenttomography AT logannicolas measurementofscleralthicknessinhumansusinganteriorsegmentopticalcoherenttomography |