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Nullspace Sampling with Holonomic Constraints Reveals Molecular Mechanisms of Protein Gαs
Proteins perform their function or interact with partners by exchanging between conformational substates on a wide range of spatiotemporal scales. Structurally characterizing these exchanges is challenging, both experimentally and computationally. Large, diffusional motions are often on timescales t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517867/ https://www.ncbi.nlm.nih.gov/pubmed/26218073 http://dx.doi.org/10.1371/journal.pcbi.1004361 |