Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity

Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments. In this study, we show that curcumin, a plant polyphenol, sensitiz...

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Detalles Bibliográficos
Autores principales: Wang, Shu-Huei, Lin, Pei-Ya, Chiu, Ya-Chen, Huang, Ju-Sui, Kuo, Yi-Tsen, Wu, Jen-Chine, Chen, Chin-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517890/
https://www.ncbi.nlm.nih.gov/pubmed/26218133
http://dx.doi.org/10.1371/journal.pone.0134110

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