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Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway
BACKGROUND: Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one possible solution to overcome the heterogeneity challenge is a shift from gene-cent...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518023/ https://www.ncbi.nlm.nih.gov/pubmed/26220863 http://dx.doi.org/10.1186/s40169-015-0066-1 |