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PI3K inhibitors in inflammation, autoimmunity and cancer
The healthy immune system protects against infection and malignant transformation without causing significant damage to host tissues. Immune dysregulation results in diverse pathologies including autoimmune disease, chronic inflammatory disorders, allergies as well as immune deficiencies and cancer....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518027/ https://www.ncbi.nlm.nih.gov/pubmed/26093105 http://dx.doi.org/10.1016/j.coph.2015.05.017 |
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author | Stark, Anne-Katrien Sriskantharajah, Srividya Hessel, Edith M Okkenhaug, Klaus |
author_facet | Stark, Anne-Katrien Sriskantharajah, Srividya Hessel, Edith M Okkenhaug, Klaus |
author_sort | Stark, Anne-Katrien |
collection | PubMed |
description | The healthy immune system protects against infection and malignant transformation without causing significant damage to host tissues. Immune dysregulation results in diverse pathologies including autoimmune disease, chronic inflammatory disorders, allergies as well as immune deficiencies and cancer. Phosphoinositide 3-kinase (PI3K) signalling has been shown to be a key pathway in the regulation of the immune response and continues to be the focus of intense research. In recent years we have gained detailed understanding of PI3K signalling, and saw the development of potent and highly selective small molecule inhibitors, of which several are currently in clinical trials for the treatment of immune-related disorders and cancer. The role of PI3K signalling in the immune response has been the subject of detailed reviews; here we focus on relevant recent progress in pre-clinical and clinical development of PI3K inhibitors. |
format | Online Article Text |
id | pubmed-4518027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-45180272015-08-01 PI3K inhibitors in inflammation, autoimmunity and cancer Stark, Anne-Katrien Sriskantharajah, Srividya Hessel, Edith M Okkenhaug, Klaus Curr Opin Pharmacol Article The healthy immune system protects against infection and malignant transformation without causing significant damage to host tissues. Immune dysregulation results in diverse pathologies including autoimmune disease, chronic inflammatory disorders, allergies as well as immune deficiencies and cancer. Phosphoinositide 3-kinase (PI3K) signalling has been shown to be a key pathway in the regulation of the immune response and continues to be the focus of intense research. In recent years we have gained detailed understanding of PI3K signalling, and saw the development of potent and highly selective small molecule inhibitors, of which several are currently in clinical trials for the treatment of immune-related disorders and cancer. The role of PI3K signalling in the immune response has been the subject of detailed reviews; here we focus on relevant recent progress in pre-clinical and clinical development of PI3K inhibitors. 2015-06-18 2015-08 /pmc/articles/PMC4518027/ /pubmed/26093105 http://dx.doi.org/10.1016/j.coph.2015.05.017 Text en © 2015 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stark, Anne-Katrien Sriskantharajah, Srividya Hessel, Edith M Okkenhaug, Klaus PI3K inhibitors in inflammation, autoimmunity and cancer |
title | PI3K inhibitors in inflammation, autoimmunity and cancer |
title_full | PI3K inhibitors in inflammation, autoimmunity and cancer |
title_fullStr | PI3K inhibitors in inflammation, autoimmunity and cancer |
title_full_unstemmed | PI3K inhibitors in inflammation, autoimmunity and cancer |
title_short | PI3K inhibitors in inflammation, autoimmunity and cancer |
title_sort | pi3k inhibitors in inflammation, autoimmunity and cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518027/ https://www.ncbi.nlm.nih.gov/pubmed/26093105 http://dx.doi.org/10.1016/j.coph.2015.05.017 |
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