Cargando…
Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial
Background. Ivermectin (IVM) has been the drug of choice for the treatment of onchocerciasis. However, there have been reports of persistent microfilaridermia in individuals from an endemic area in Ghana after many rounds of IVM, raising concerns of suboptimal response or even the emergence of drug...
Autores principales: | Debrah, Alexander Yaw, Specht, Sabine, Klarmann-Schulz, Ute, Batsa, Linda, Mand, Sabine, Marfo-Debrekyei, Yeboah, Fimmers, Rolf, Dubben, Bettina, Kwarteng, Alexander, Osei-Atweneboana, Mike, Boakye, Daniel, Ricchiuto, Arcangelo, Büttner, Marcelle, Adjei, Ohene, Mackenzie, Charles D., Hoerauf, Achim |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518165/ https://www.ncbi.nlm.nih.gov/pubmed/25948064 http://dx.doi.org/10.1093/cid/civ363 |
Ejemplares similares
-
Doxycycline Improves Filarial Lymphedema Independent of Active Filarial
Infection: A Randomized Controlled Trial
por: Mand, Sabine, et al.
Publicado: (2012) -
Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals
por: Arndts, Kathrin, et al.
Publicado: (2015) -
Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline
por: Debrah, Alexander Yaw, et al.
Publicado: (2011) -
Frequent detection of worm movements in onchocercal nodules by ultrasonography
por: Mand, Sabine, et al.
Publicado: (2005) -
Lymphatic Vascularisation and Involvement of Lyve-1(+) Macrophages in the Human Onchocerca Nodule
por: Attout, Tarik, et al.
Publicado: (2009)