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Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding

Objectives: Gastroschisis is a congenital anomaly affecting 2.3-4.4/10,000 births. Previous studies show initiation of early enteral feeds predicts improved outcomes. We hypothesize that earlier definitive closure after silo placement; can lead to earlier enteral feed initiation. Design/ Setting/ Du...

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Autores principales: Harris, Jamie, Poirier, Jennifer, Selip, Debra, Pillai, Srikumar, N. Shah, Ami, Jackson, Carl-Christian, Chiu, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EL-MED-Pub 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518187/
https://www.ncbi.nlm.nih.gov/pubmed/26290810
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author Harris, Jamie
Poirier, Jennifer
Selip, Debra
Pillai, Srikumar
N. Shah, Ami
Jackson, Carl-Christian
Chiu, Bill
author_facet Harris, Jamie
Poirier, Jennifer
Selip, Debra
Pillai, Srikumar
N. Shah, Ami
Jackson, Carl-Christian
Chiu, Bill
author_sort Harris, Jamie
collection PubMed
description Objectives: Gastroschisis is a congenital anomaly affecting 2.3-4.4/10,000 births. Previous studies show initiation of early enteral feeds predicts improved outcomes. We hypothesize that earlier definitive closure after silo placement; can lead to earlier enteral feed initiation. Design/ Setting/ Duration: Retrospective review of patients with gastroschisis from 2005 and 2014 at a single institution. Material and Methods: The data, including ethnicity, gestational age, birth weight, time to definitive closure, and time of first and full feeds, were analyzed using both Spearman’s rho and the Kruskal-Wallis rank sum test where appropriate; a p value less than 0.05 was considered significant. Results: Forty-three patients (24 males, 19 females) born with gastroschisis were identified. Overall survival rate was 88% (38/43). Forty of the 43 patients had a silo placed prior to definitive closure. Median days to closure were 6 (0 to 85) days. First feeds on average began on day of life (DOL) 17, and full feeds on DOL 25. Earlier closure of gastroschisis correlated with early initiation of feeds (p=0.0001) and shorter time to full feeds (p=0.018), closure by DOL4 showed a trend toward earlier feeding (p=0.13). Conclusion: Earlier closure of gastroschisis after silo placement was associated with earlier feed initiation and shorter time to full feeds.
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spelling pubmed-45181872015-08-19 Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding Harris, Jamie Poirier, Jennifer Selip, Debra Pillai, Srikumar N. Shah, Ami Jackson, Carl-Christian Chiu, Bill J Neonatal Surg Original Article Objectives: Gastroschisis is a congenital anomaly affecting 2.3-4.4/10,000 births. Previous studies show initiation of early enteral feeds predicts improved outcomes. We hypothesize that earlier definitive closure after silo placement; can lead to earlier enteral feed initiation. Design/ Setting/ Duration: Retrospective review of patients with gastroschisis from 2005 and 2014 at a single institution. Material and Methods: The data, including ethnicity, gestational age, birth weight, time to definitive closure, and time of first and full feeds, were analyzed using both Spearman’s rho and the Kruskal-Wallis rank sum test where appropriate; a p value less than 0.05 was considered significant. Results: Forty-three patients (24 males, 19 females) born with gastroschisis were identified. Overall survival rate was 88% (38/43). Forty of the 43 patients had a silo placed prior to definitive closure. Median days to closure were 6 (0 to 85) days. First feeds on average began on day of life (DOL) 17, and full feeds on DOL 25. Earlier closure of gastroschisis correlated with early initiation of feeds (p=0.0001) and shorter time to full feeds (p=0.018), closure by DOL4 showed a trend toward earlier feeding (p=0.13). Conclusion: Earlier closure of gastroschisis after silo placement was associated with earlier feed initiation and shorter time to full feeds. EL-MED-Pub 2015-07-01 /pmc/articles/PMC4518187/ /pubmed/26290810 Text en Copyright: © 2015 JNS http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Harris, Jamie
Poirier, Jennifer
Selip, Debra
Pillai, Srikumar
N. Shah, Ami
Jackson, Carl-Christian
Chiu, Bill
Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding
title Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding
title_full Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding
title_fullStr Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding
title_full_unstemmed Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding
title_short Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding
title_sort early closure of gastroschisis after silo placement correlates with earlier enteral feeding
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518187/
https://www.ncbi.nlm.nih.gov/pubmed/26290810
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