Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix

Collagens, the most abundant proteins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating sequence, where Xaa is often proline and Yaa, hydroxyproline (Hyp/O). It is known that hydroxyproline in the Yaa position stabilises the triple helix, and that lack...

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Detalles Bibliográficos
Autores principales: Ying Chow, W., Bihan, Dominique, Forman, Chris J., Slatter, David A., Reid, David G., Wales, David J., Farndale, Richard W., Duer, Melinda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518226/
https://www.ncbi.nlm.nih.gov/pubmed/26220399
http://dx.doi.org/10.1038/srep12556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518226/
https://www.ncbi.nlm.nih.gov/pubmed/26220399
http://dx.doi.org/10.1038/srep12556

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