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Sirt1-deficiency causes defective protein quality control

Protein quality control is an important mechanism to maintain cellular homeostasis. Damaged proteins have to be restored or eliminated by degradation, which is mainly achieved by molecular chaperones and the ubiquitin-proteasome system. The NAD(+)-dependent deacetylase Sirt1 has been reported to pla...

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Detalles Bibliográficos
Autores principales:	Tomita, Takuya, Hamazaki, Jun, Hirayama, Shoshiro, McBurney, Michael W., Yashiroda, Hideki, Murata, Shigeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518232/ https://www.ncbi.nlm.nih.gov/pubmed/26219988 http://dx.doi.org/10.1038/srep12613

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