Locking GTPases covalently in their functional states

GTPases act as key regulators of many cellular processes by switching between active (GTP-bound) and inactive (GDP-bound) states. In many cases, understanding their mode of action has been aided by artificially stabilizing one of these states either by designing mutant proteins or by complexation wi...

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Detalles Bibliográficos
Autores principales: Wiegandt, David, Vieweg, Sophie, Hofmann, Frank, Koch, Daniel, Li, Fu, Wu, Yao-Wen, Itzen, Aymelt, Müller, Matthias P., Goody, Roger S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518245/
https://www.ncbi.nlm.nih.gov/pubmed/26178622
http://dx.doi.org/10.1038/ncomms8773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518245/
https://www.ncbi.nlm.nih.gov/pubmed/26178622
http://dx.doi.org/10.1038/ncomms8773

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