Cargando…

Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

The medial prefrontal cortex (mPFC) is implicated in processing sensory-discriminative and affective pain. Nonetheless, the underlying mechanisms are poorly understood. Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC, in the regulation of pain sen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Guo-Qiang, Cen, Cheng, Li, Chong, Cao, Shuai, Wang, Ning, Zhou, Zheng, Liu, Xue-Mei, Xu, Yu, Tian, Na-Xi, Zhang, Ying, Wang, Jun, Wang, Li-Ping, Wang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518290/ https://www.ncbi.nlm.nih.gov/pubmed/26179626 http://dx.doi.org/10.1038/ncomms8660

Ejemplares similares

Corrigendum: Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety
por: Wang, Guo-Qiang, et al.
Publicado: (2016)

Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice
por: Jiang, Li-Xin, et al.
Publicado: (2023)

Serotonergic Regulation of Corticoamygdalar Neurons in the Mouse Prelimbic Cortex
por: Avesar, Daniel, et al.
Publicado: (2018)

Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors
por: Luo, Yi-Fan, et al.
Publicado: (2023)

Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward
por: Jiang, Changyou, et al.
Publicado: (2019)

Morphological Responses of Excitatory Prelimbic and Orbitofrontal Cortical Neurons to Excess Corticosterone in Adolescence and Acute Stress in Adulthood
por: Barfield, Elizabeth T., et al.
Publicado: (2020)

Hypersensitivity of Prelimbic Cortex Neurons Contributes to Aggravated Nociceptive Responses in Rats With Experience of Chronic Inflammatory Pain
por: Fan, Xiao-Cen, et al.
Publicado: (2018)

The prelimbic cortex regulates itch processing by controlling attentional bias
por: Wu, Guang-Yan, et al.
Publicado: (2022)

Blockade of Glutamate Receptors within the Prelimbic Cortex Attenuate Concentration of Excitatory Amino Acids in the Morphine Self-administration in Rats
por: Aboutalebi, Fateme, et al.
Publicado: (2018)

Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity
por: Udakis, Matthew, et al.
Publicado: (2016)

Encoding of social novelty by sparse GABAergic neural ensembles in the prelimbic cortex
por: Zhao, Zhe, et al.
Publicado: (2022)

Excitatory neuronal connectivity in the barrel cortex
por: Feldmeyer, Dirk
Publicado: (2012)

Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core
por: James, Morgan H, et al.
Publicado: (2017)

Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain
por: Gao, Feng, et al.
Publicado: (2023)

β2-Adrenoceptors in the Medial Prefrontal Cortex Excitatory Neurons Regulate Anxiety-like Behavior in Mice
por: Lei, Zhuogui, et al.
Publicado: (2022)

The prelimbic cortex is critical for context-dependent fear expression
por: Kim, Eun Joo, et al.
Publicado: (2013)

Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats
por: Yuan, Chengdong, et al.
Publicado: (2016)

NPY(+)-, but not PV(+)-GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex
por: Saffari, R, et al.
Publicado: (2016)

Specific Targeting of the Basolateral Amygdala to Projectionally Defined Pyramidal Neurons in Prelimbic and Infralimbic Cortex123
por: Cheriyan, John, et al.
Publicado: (2016)

ErbB4 signaling in the prelimbic cortex regulates fear expression
por: Chen, Y-H, et al.
Publicado: (2017)

Pinpointing Morphology and Projection of Excitatory Neurons in Mouse Visual Cortex
por: Zhang, Yalun, et al.
Publicado: (2019)

Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs
por: Zhang, Guanjun, et al.
Publicado: (2013)

Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
por: Diehl, Maria M, et al.
Publicado: (2020)

Axonal Dynamics of Excitatory and Inhibitory Neurons in Somatosensory Cortex
por: Marik, Sally A., et al.
Publicado: (2010)

Neuronal Nicotinic Receptors Are Crucial for Tuning of E/I Balance in Prelimbic Cortex and for Decision-Making Processes
por: Pittaras, Elsa Cécile, et al.
Publicado: (2016)

The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch
por: Yao, Juan, et al.
Publicado: (2023)

Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
por: van Aerde, Karlijn I., et al.
Publicado: (2008)

Activity in prelimbic cortex subserves fear memory reconsolidation over time
por: Stern, Cristina A.J., et al.
Publicado: (2014)

Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum
por: Bravo-Rivera, Christian, et al.
Publicado: (2015)

Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories
por: Ye, Xiaojing, et al.
Publicado: (2016)

Inactivation of the Prelimbic Cortex Impairs the Context-Induced Reinstatement of Ethanol Seeking
por: Palombo, Paola, et al.
Publicado: (2017)

Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
por: Diehl, Maria M, et al.
Publicado: (2018)

Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex
por: Fernandez-Leon, Jose A, et al.
Publicado: (2021)

Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex
por: Sequeira, Michelle K., et al.
Publicado: (2023)

Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changes
por: Perez-Cruz, Claudia, et al.
Publicado: (2009)

Mouse models of surgical and neuropathic pain produce distinct functional alterations to prodynorphin expressing neurons in the prelimbic cortex
por: Zhou, Shudi, et al.
Publicado: (2023)

Prognostic Value of Posteromedial Cortex Deactivation in Mild Cognitive Impairment
por: Petrella, Jeffrey R., et al.
Publicado: (2007)

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons
por: Takahashi, Miyuki, et al.
Publicado: (2022)

Catecholaminergic depletion within the prelimbic medial prefrontal cortex enhances latent inhibition
por: Nelson, A.J.D., et al.
Publicado: (2010)

Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females
por: Fenton, Georgina E., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_b90cg45e6nq7e3u4q6hrc35p76