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Parallel circuits control temperature preference in Drosophila during ageing

The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well under...

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Autores principales: Shih, Hsiang-Wen, Wu, Chia-Lin, Chang, Sue-Wei, Liu, Tsung-Ho, Sih-Yu Lai, Jason, Fu, Tsai-Feng, Fu, Chien-Chung, Chiang, Ann-Shyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518306/
https://www.ncbi.nlm.nih.gov/pubmed/26178754
http://dx.doi.org/10.1038/ncomms8775
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author Shih, Hsiang-Wen
Wu, Chia-Lin
Chang, Sue-Wei
Liu, Tsung-Ho
Sih-Yu Lai, Jason
Fu, Tsai-Feng
Fu, Chien-Chung
Chiang, Ann-Shyn
author_facet Shih, Hsiang-Wen
Wu, Chia-Lin
Chang, Sue-Wei
Liu, Tsung-Ho
Sih-Yu Lai, Jason
Fu, Tsai-Feng
Fu, Chien-Chung
Chiang, Ann-Shyn
author_sort Shih, Hsiang-Wen
collection PubMed
description The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well understood. Here, we identify an age-related change in the temperature preference of adult fruit flies that results from a shift in the relative contributions of two parallel mushroom body (MB) circuits—the β′- and β-systems. The β′-circuit primarily controls cold avoidance through dopamine signalling in young flies, whereas the β-circuit increasingly contributes to cold avoidance as adult flies age. Elevating dopamine levels in β′-afferent neurons of aged flies restores cold sensitivity, suggesting that the alteration of cold avoidance behaviour with ageing is functionally reversible. These results provide a framework for investigating how molecules and individual neural circuits modulate homeostatic alterations during the course of senescence.
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spelling pubmed-45183062015-08-07 Parallel circuits control temperature preference in Drosophila during ageing Shih, Hsiang-Wen Wu, Chia-Lin Chang, Sue-Wei Liu, Tsung-Ho Sih-Yu Lai, Jason Fu, Tsai-Feng Fu, Chien-Chung Chiang, Ann-Shyn Nat Commun Article The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well understood. Here, we identify an age-related change in the temperature preference of adult fruit flies that results from a shift in the relative contributions of two parallel mushroom body (MB) circuits—the β′- and β-systems. The β′-circuit primarily controls cold avoidance through dopamine signalling in young flies, whereas the β-circuit increasingly contributes to cold avoidance as adult flies age. Elevating dopamine levels in β′-afferent neurons of aged flies restores cold sensitivity, suggesting that the alteration of cold avoidance behaviour with ageing is functionally reversible. These results provide a framework for investigating how molecules and individual neural circuits modulate homeostatic alterations during the course of senescence. Nature Pub. Group 2015-07-16 /pmc/articles/PMC4518306/ /pubmed/26178754 http://dx.doi.org/10.1038/ncomms8775 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Shih, Hsiang-Wen
Wu, Chia-Lin
Chang, Sue-Wei
Liu, Tsung-Ho
Sih-Yu Lai, Jason
Fu, Tsai-Feng
Fu, Chien-Chung
Chiang, Ann-Shyn
Parallel circuits control temperature preference in Drosophila during ageing
title Parallel circuits control temperature preference in Drosophila during ageing
title_full Parallel circuits control temperature preference in Drosophila during ageing
title_fullStr Parallel circuits control temperature preference in Drosophila during ageing
title_full_unstemmed Parallel circuits control temperature preference in Drosophila during ageing
title_short Parallel circuits control temperature preference in Drosophila during ageing
title_sort parallel circuits control temperature preference in drosophila during ageing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518306/
https://www.ncbi.nlm.nih.gov/pubmed/26178754
http://dx.doi.org/10.1038/ncomms8775
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