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Parallel circuits control temperature preference in Drosophila during ageing
The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well under...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518306/ https://www.ncbi.nlm.nih.gov/pubmed/26178754 http://dx.doi.org/10.1038/ncomms8775 |
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author | Shih, Hsiang-Wen Wu, Chia-Lin Chang, Sue-Wei Liu, Tsung-Ho Sih-Yu Lai, Jason Fu, Tsai-Feng Fu, Chien-Chung Chiang, Ann-Shyn |
author_facet | Shih, Hsiang-Wen Wu, Chia-Lin Chang, Sue-Wei Liu, Tsung-Ho Sih-Yu Lai, Jason Fu, Tsai-Feng Fu, Chien-Chung Chiang, Ann-Shyn |
author_sort | Shih, Hsiang-Wen |
collection | PubMed |
description | The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well understood. Here, we identify an age-related change in the temperature preference of adult fruit flies that results from a shift in the relative contributions of two parallel mushroom body (MB) circuits—the β′- and β-systems. The β′-circuit primarily controls cold avoidance through dopamine signalling in young flies, whereas the β-circuit increasingly contributes to cold avoidance as adult flies age. Elevating dopamine levels in β′-afferent neurons of aged flies restores cold sensitivity, suggesting that the alteration of cold avoidance behaviour with ageing is functionally reversible. These results provide a framework for investigating how molecules and individual neural circuits modulate homeostatic alterations during the course of senescence. |
format | Online Article Text |
id | pubmed-4518306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45183062015-08-07 Parallel circuits control temperature preference in Drosophila during ageing Shih, Hsiang-Wen Wu, Chia-Lin Chang, Sue-Wei Liu, Tsung-Ho Sih-Yu Lai, Jason Fu, Tsai-Feng Fu, Chien-Chung Chiang, Ann-Shyn Nat Commun Article The detection of environmental temperature and regulation of body temperature are integral determinants of behaviour for all animals. These functions become less efficient in aged animals, particularly during exposure to cold environments, yet the cellular and molecular mechanisms are not well understood. Here, we identify an age-related change in the temperature preference of adult fruit flies that results from a shift in the relative contributions of two parallel mushroom body (MB) circuits—the β′- and β-systems. The β′-circuit primarily controls cold avoidance through dopamine signalling in young flies, whereas the β-circuit increasingly contributes to cold avoidance as adult flies age. Elevating dopamine levels in β′-afferent neurons of aged flies restores cold sensitivity, suggesting that the alteration of cold avoidance behaviour with ageing is functionally reversible. These results provide a framework for investigating how molecules and individual neural circuits modulate homeostatic alterations during the course of senescence. Nature Pub. Group 2015-07-16 /pmc/articles/PMC4518306/ /pubmed/26178754 http://dx.doi.org/10.1038/ncomms8775 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Shih, Hsiang-Wen Wu, Chia-Lin Chang, Sue-Wei Liu, Tsung-Ho Sih-Yu Lai, Jason Fu, Tsai-Feng Fu, Chien-Chung Chiang, Ann-Shyn Parallel circuits control temperature preference in Drosophila during ageing |
title | Parallel circuits control temperature preference in Drosophila during ageing |
title_full | Parallel circuits control temperature preference in Drosophila during ageing |
title_fullStr | Parallel circuits control temperature preference in Drosophila during ageing |
title_full_unstemmed | Parallel circuits control temperature preference in Drosophila during ageing |
title_short | Parallel circuits control temperature preference in Drosophila during ageing |
title_sort | parallel circuits control temperature preference in drosophila during ageing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518306/ https://www.ncbi.nlm.nih.gov/pubmed/26178754 http://dx.doi.org/10.1038/ncomms8775 |
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