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Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity

Amyloidosis may involve the respiratory system with different clinical-radiological-functional patterns which are not always easy to be recognized. A good level of knowledge of the disease, an active integration of the pulmonologist within a multidisciplinary setting and a high level of clinical sus...

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Autores principales: Scala, Raffaele, Maccari, Uberto, Madioni, Chiara, Venezia, Duccio, La Magra, Lidia Calogera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518353/
https://www.ncbi.nlm.nih.gov/pubmed/26229565
http://dx.doi.org/10.4103/1817-1737.157290
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author Scala, Raffaele
Maccari, Uberto
Madioni, Chiara
Venezia, Duccio
La Magra, Lidia Calogera
author_facet Scala, Raffaele
Maccari, Uberto
Madioni, Chiara
Venezia, Duccio
La Magra, Lidia Calogera
author_sort Scala, Raffaele
collection PubMed
description Amyloidosis may involve the respiratory system with different clinical-radiological-functional patterns which are not always easy to be recognized. A good level of knowledge of the disease, an active integration of the pulmonologist within a multidisciplinary setting and a high level of clinical suspicion are necessary for an early diagnosis of respiratory amyloidosis. The aim of this retrospective study was to evaluate the number and the patterns of amyloidosis involving the respiratory system. We searched the cases of amyloidosis among patients attending the multidisciplinary rare and diffuse lung disease outpatients' clinic of Pulmonology Unit of the Hospital of Arezzo from 2007 to 2012. Among the 298 patients evaluated during the study period, we identified three cases of amyloidosis with involvement of the respiratory system, associated or not with other extra-thoracic localizations, whose diagnosis was histo-pathologically confirmed after the pulmonologist, the radiologist, and the pathologist evaluation. Our experience of a multidisciplinary team confirms that intra-thoracic amyloidosis is an uncommon disorder, representing 1.0% of the cases of rare and diffuse lung diseases referred to our center. The diagnosis of the disease is not always easy and quick as the amyloidosis may involve different parts of the respiratory system (airways, pleura, parenchyma). It is therefore recommended to remind this orphan disease in the differential diagnosis of the wide clinical scenarios the pulmonologist may intercept in clinical practice.
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spelling pubmed-45183532015-07-30 Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity Scala, Raffaele Maccari, Uberto Madioni, Chiara Venezia, Duccio La Magra, Lidia Calogera Ann Thorac Med Case Report Amyloidosis may involve the respiratory system with different clinical-radiological-functional patterns which are not always easy to be recognized. A good level of knowledge of the disease, an active integration of the pulmonologist within a multidisciplinary setting and a high level of clinical suspicion are necessary for an early diagnosis of respiratory amyloidosis. The aim of this retrospective study was to evaluate the number and the patterns of amyloidosis involving the respiratory system. We searched the cases of amyloidosis among patients attending the multidisciplinary rare and diffuse lung disease outpatients' clinic of Pulmonology Unit of the Hospital of Arezzo from 2007 to 2012. Among the 298 patients evaluated during the study period, we identified three cases of amyloidosis with involvement of the respiratory system, associated or not with other extra-thoracic localizations, whose diagnosis was histo-pathologically confirmed after the pulmonologist, the radiologist, and the pathologist evaluation. Our experience of a multidisciplinary team confirms that intra-thoracic amyloidosis is an uncommon disorder, representing 1.0% of the cases of rare and diffuse lung diseases referred to our center. The diagnosis of the disease is not always easy and quick as the amyloidosis may involve different parts of the respiratory system (airways, pleura, parenchyma). It is therefore recommended to remind this orphan disease in the differential diagnosis of the wide clinical scenarios the pulmonologist may intercept in clinical practice. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4518353/ /pubmed/26229565 http://dx.doi.org/10.4103/1817-1737.157290 Text en Copyright: © Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Scala, Raffaele
Maccari, Uberto
Madioni, Chiara
Venezia, Duccio
La Magra, Lidia Calogera
Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
title Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
title_full Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
title_fullStr Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
title_full_unstemmed Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
title_short Amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
title_sort amyloidosis involving the respiratory system: 5-year's experience of a multi-disciplinary group's activity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518353/
https://www.ncbi.nlm.nih.gov/pubmed/26229565
http://dx.doi.org/10.4103/1817-1737.157290
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