MYC Is a Major Determinant of Mitotic Cell Fate

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer. Using time-lapse imaging to correlate mitotic beha...

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Detalles Bibliográficos
Autores principales: Topham, Caroline, Tighe, Anthony, Ly, Peter, Bennett, Ailsa, Sloss, Olivia, Nelson, Louisa, Ridgway, Rachel A., Huels, David, Littler, Samantha, Schandl, Claudia, Sun, Ying, Bechi, Beatrice, Procter, David J., Sansom, Owen J., Cleveland, Don W., Taylor, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518499/
https://www.ncbi.nlm.nih.gov/pubmed/26175417
http://dx.doi.org/10.1016/j.ccell.2015.06.001

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