An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

INTRODUCTION: Amyloid-β (Aβ) has been investigated as a diagnostic biomarker and therapeutic drug target. Recent studies found that cerebrospinal fluid (CSF) Aβ fluctuates over time, including as a diurnal pattern, and increases in absolute concentration with serial collection. It is currently unkno...

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Detalles Bibliográficos
Autores principales: Lucey, Brendan P., Gonzales, Celedon, Das, Ujjwas, Li, Jinhe, Siemers, Eric R., Slemmon, J. Randall, Bateman, Randall J., Huang, Yafei, Fox, Gerard B., Claassen, Jurgen A.H.R., Slats, Diane, Verbeek, Marcel M., Tong, Gary, Soares, Holly, Savage, Mary J., Kennedy, Matthew, Forman, Mark, Sjögren, Magnus, Margolin, Richard, Chen, Xia, Farlow, Martin R., Dean, Robert A., Waring, Jeffrey F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518529/
https://www.ncbi.nlm.nih.gov/pubmed/26225140
http://dx.doi.org/10.1186/s13195-015-0136-z

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