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T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment
BACKGROUND: T cell function is crucial for the success of several novel immunotherapeutic strategies for the treatment of acute myeloid leukemia (AML). However, changes in phenotype and function of T cells have been described in various hematologic malignancies, mimicking T cell exhaustion known fro...
Autores principales: | Schnorfeil, Frauke M., Lichtenegger, Felix S., Emmerig, Katharina, Schlueter, Miriam, Neitz, Julia S., Draenert, Rika, Hiddemann, Wolfgang, Subklewe, Marion |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518596/ https://www.ncbi.nlm.nih.gov/pubmed/26219463 http://dx.doi.org/10.1186/s13045-015-0189-2 |
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