T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment

BACKGROUND: T cell function is crucial for the success of several novel immunotherapeutic strategies for the treatment of acute myeloid leukemia (AML). However, changes in phenotype and function of T cells have been described in various hematologic malignancies, mimicking T cell exhaustion known fro...

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Detalles Bibliográficos
Autores principales: Schnorfeil, Frauke M., Lichtenegger, Felix S., Emmerig, Katharina, Schlueter, Miriam, Neitz, Julia S., Draenert, Rika, Hiddemann, Wolfgang, Subklewe, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518596/
https://www.ncbi.nlm.nih.gov/pubmed/26219463
http://dx.doi.org/10.1186/s13045-015-0189-2

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