Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas

Bcl11b is a transcription factor important for T cell development and also a tumor-suppressor gene that is hemizygously inactivated in ~10 % human T cell acute lymphoblastic leukemia (T-ALL) and several murine T-ALL models, including ATM(−/−) thymic lymphomas. Here we report that heterozygous loss o...

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Detalles Bibliográficos
Autores principales: Pinkney, Kerice A., Jiang, Wenxia, Lee, Brian J., Loredan, Denis G., Li, Chen, Bhagat, Govind, Zha, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518599/
https://www.ncbi.nlm.nih.gov/pubmed/26219558
http://dx.doi.org/10.1186/s13045-015-0191-8

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