Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

The canonical action of the p85α regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is to associate with the p110α catalytic subunit to allow stimuli-dependent activation of the PI3K pathway. We elucidate a p110α-independent role of homodimerized p85α in the positive regulation of PTEN stabi...

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Detalles Bibliográficos
Autores principales: Cheung, Lydia WT, Walkiewicz, Katarzyna W, Besong, Tabot MD, Guo, Huifang, Hawke, David H, Arold, Stefan T, Mills, Gordon B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518712/
https://www.ncbi.nlm.nih.gov/pubmed/26222500
http://dx.doi.org/10.7554/eLife.06866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518712/
https://www.ncbi.nlm.nih.gov/pubmed/26222500
http://dx.doi.org/10.7554/eLife.06866

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