Cargando…

PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation

Detalles Bibliográficos
Autores principales:	Margaria, JP, Franco, I, Ranghino, A, Monteyne, D, Chiaravalli, M, Pema, M, Campa, C, Gulluni, F, Perez-Morga, D, Merlo, G, Boletta, A, Hirsch, E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Oral Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519123/ http://dx.doi.org/10.1186/2046-2530-4-S1-O1

Ejemplares similares

PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium
por: Franco, I, et al.
Publicado: (2012)

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex
por: Pema, Monika, et al.
Publicado: (2016)

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus
por: Wodarczyk, Claas, et al.
Publicado: (2009)

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function
por: Franco, Irene, et al.
Publicado: (2014)

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness
por: Nigro, Elisa Agnese, et al.
Publicado: (2019)

Polycystin-2 takes different routes to the somatic and ciliary plasma membrane
por: Hoffmeister, Helen, et al.
Publicado: (2011)

Polycystin-1 Binds Par3/aPKC and Controls Convergent Extension During Renal Tubular Morphogenesis
por: Castelli, Maddalena, et al.
Publicado: (2013)

Emerging evidence of a link between the polycystins and the mTOR pathways
por: Boletta, Alessandra
Publicado: (2009)

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis
por: Nigro, Elisa Agnese, et al.
Publicado: (2015)

Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain
por: Vien, Thuy N., et al.
Publicado: (2020)

A polycystin-centric view of cyst formation and disease: the polycystins revisited
por: Ong, Albert CM, et al.
Publicado: (2015)

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca(2+) Entry through Interactions with STIM1
por: Woodward, Owen M., et al.
Publicado: (2010)

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex
por: Wang, Zhifei, et al.
Publicado: (2019)

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2
por: Wang, Qinrui, et al.
Publicado: (2020)

A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1
por: Ward, Heather H., et al.
Publicado: (2011)

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
por: Walker, Rebecca V., et al.
Publicado: (2019)

Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency
por: Chang, Ming-Yang, et al.
Publicado: (2017)

Polycystins and cellular Ca(2+) signaling
por: Mekahli, D., et al.
Publicado: (2012)

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes
por: Giamarchi, Aurélie, et al.
Publicado: (2010)

Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner
por: Waheed, A, et al.
Publicado: (2014)

Polycystin-2 Associates With Malignancy in Meningiomas
por: Assimakopoulou, Martha, et al.
Publicado: (2023)

Quantitative analysis of ciliary beating in primary ciliary dyskinesia: a pilot study
por: Papon, J-F, et al.
Publicado: (2012)

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration
por: Castelli, Maddalena, et al.
Publicado: (2015)

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function
por: Padovano, Valeria, et al.
Publicado: (2017)

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
por: MacKay, Charles E, et al.
Publicado: (2022)

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts
por: Grosch, Melanie, et al.
Publicado: (2021)

Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease
por: Lee, Seung Hun, et al.
Publicado: (2014)

Identification of Polycystin-2 and CFTR common targets
por: Roxo-Rosa, M, et al.
Publicado: (2015)

Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site
por: Chapin, Hannah C., et al.
Publicado: (2010)

The architectural landscape of diverse ciliary functions
por: Bettencourt-Dias, M, et al.
Publicado: (2015)

Nephrocystin-1 Forms a Complex with Polycystin-1 via a Polyproline Motif/SH3 Domain Interaction and Regulates the Apoptotic Response in Mammals
por: Wodarczyk, Claas, et al.
Publicado: (2010)

OFD1 and Flotillins Are Integral Components of a Ciliary Signaling Protein Complex Organized by Polycystins in Renal Epithelia and Odontoblasts
por: Jerman, Stephanie, et al.
Publicado: (2014)

Polycystins and mechanotransduction in bone
por: Gargalionis, Antonios N., et al.
Publicado: (2017)

Polycystins in Colorectal Cancer
por: Gargalionis, Antonios N., et al.
Publicado: (2018)

NPHP and MKS proteins and the ciliary transition zone
por: Yoder, BK
Publicado: (2012)

Structural Interaction and Functional Regulation of Polycystin-2 by Filamin
por: Wang, Qian, et al.
Publicado: (2012)

Intracellular calcium release modulates polycystin-2 trafficking
por: Miyakawa, Ayako, et al.
Publicado: (2013)

The Polycystin complex mediates WNT/Ca(2+) signaling
por: Kim, Seokho, et al.
Publicado: (2016)

Hyperosmotic stress stimulates autophagy via polycystin-2
por: Peña-Oyarzun, Daniel, et al.
Publicado: (2017)

Managed entry agreements
por: Muscolo, Luisa AA, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8j92p64bulaqmticis0dndfp6h