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Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function

The ABL protein-tyrosine kinase regulates intracellular signaling pathways controlling diverse cellular processes and contributes to several forms of cancer. The kinase activity of ABL is repressed by intramolecular interactions involving its regulatory Ncap, SH3 and SH2 domains. Small molecules tha...

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Detalles Bibliográficos
Autores principales:	Grover, Prerna, Shi, Haibin, Baumgartner, Matthew, Camacho, Carlos J., Smithgall, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519180/ https://www.ncbi.nlm.nih.gov/pubmed/26222440 http://dx.doi.org/10.1371/journal.pone.0133590

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