Pharmacological Suppression of CNS Scarring by Deferoxamine Reduces Lesion Volume and Increases Regeneration in an In Vitro Model for Astroglial-Fibrotic Scarring and in Rat Spinal Cord Injury In Vivo

Lesion-induced scarring is a major impediment for regeneration of injured axons in the central nervous system (CNS). The collagen-rich glial-fibrous scar contains numerous axon growth inhibitory factors forming a regeneration-barrier for axons. We demonstrated previously that the combination of the...

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Detalles Bibliográficos
Autores principales: Vogelaar, Christina Francisca, König, Brigitte, Krafft, Stefanie, Estrada, Veronica, Brazda, Nicole, Ziegler, Brigida, Faissner, Andreas, Müller, Hans Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519270/
https://www.ncbi.nlm.nih.gov/pubmed/26222542
http://dx.doi.org/10.1371/journal.pone.0134371

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