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Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species

The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was t...

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Autores principales: Antonissen, Gunther, Devreese, Mathias, De Baere, Siegrid, Hellebuyck, Tom, Van de Maele, Isabel, Rouffaer, Lieze, Stemkens, Hendrickus J. J., De Backer, Patrick, Martel, An, Croubels, Siska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519271/
https://www.ncbi.nlm.nih.gov/pubmed/26222777
http://dx.doi.org/10.1371/journal.pone.0134177
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author Antonissen, Gunther
Devreese, Mathias
De Baere, Siegrid
Hellebuyck, Tom
Van de Maele, Isabel
Rouffaer, Lieze
Stemkens, Hendrickus J. J.
De Backer, Patrick
Martel, An
Croubels, Siska
author_facet Antonissen, Gunther
Devreese, Mathias
De Baere, Siegrid
Hellebuyck, Tom
Van de Maele, Isabel
Rouffaer, Lieze
Stemkens, Hendrickus J. J.
De Backer, Patrick
Martel, An
Croubels, Siska
author_sort Antonissen, Gunther
collection PubMed
description The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was to investigate the pharmacokinetics of carboplatin in a representative species of the order of Galliformes, Anseriformes, Columbiformes and Psittaciformes. Eight chickens, ducks and pigeons and twenty-eight parakeets were administered carboplatin intravenously (5 mg/kg body weight). A specific and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of the free carboplatin in plasma of the four birds species (limit of quantification: 20 ng/mL for chicken and duck, 50 ng/mL for pigeon and 100 ng/mL for parakeets). Non-compartmental pharmacokinetic analysis and allometric scaling demonstrated a significant correlation (R(²) = 0.9769) between body weight (BW) and elimination half-life (T(1/2el)). T(1/2el) ranged from 0.41 h in parakeets (BW: 61 ± 8 g) to 1.16 h chickens (BW: 1909 ± 619 g). T(1/2el) is a good parameter for dose optimization of carboplatin in other avian species, since also the previously reported T(1/2el) in cockatoos (average BW: 769 ± 68 g) of 1.00 h corresponds to the results obtained in the present study.
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spelling pubmed-45192712015-07-31 Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species Antonissen, Gunther Devreese, Mathias De Baere, Siegrid Hellebuyck, Tom Van de Maele, Isabel Rouffaer, Lieze Stemkens, Hendrickus J. J. De Backer, Patrick Martel, An Croubels, Siska PLoS One Research Article The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was to investigate the pharmacokinetics of carboplatin in a representative species of the order of Galliformes, Anseriformes, Columbiformes and Psittaciformes. Eight chickens, ducks and pigeons and twenty-eight parakeets were administered carboplatin intravenously (5 mg/kg body weight). A specific and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for quantification of the free carboplatin in plasma of the four birds species (limit of quantification: 20 ng/mL for chicken and duck, 50 ng/mL for pigeon and 100 ng/mL for parakeets). Non-compartmental pharmacokinetic analysis and allometric scaling demonstrated a significant correlation (R(²) = 0.9769) between body weight (BW) and elimination half-life (T(1/2el)). T(1/2el) ranged from 0.41 h in parakeets (BW: 61 ± 8 g) to 1.16 h chickens (BW: 1909 ± 619 g). T(1/2el) is a good parameter for dose optimization of carboplatin in other avian species, since also the previously reported T(1/2el) in cockatoos (average BW: 769 ± 68 g) of 1.00 h corresponds to the results obtained in the present study. Public Library of Science 2015-07-29 /pmc/articles/PMC4519271/ /pubmed/26222777 http://dx.doi.org/10.1371/journal.pone.0134177 Text en © 2015 Antonissen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Antonissen, Gunther
Devreese, Mathias
De Baere, Siegrid
Hellebuyck, Tom
Van de Maele, Isabel
Rouffaer, Lieze
Stemkens, Hendrickus J. J.
De Backer, Patrick
Martel, An
Croubels, Siska
Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species
title Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species
title_full Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species
title_fullStr Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species
title_full_unstemmed Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species
title_short Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species
title_sort comparative pharmacokinetics and allometric scaling of carboplatin in different avian species
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519271/
https://www.ncbi.nlm.nih.gov/pubmed/26222777
http://dx.doi.org/10.1371/journal.pone.0134177
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