Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis

Neuroblastoma is a pediatric malignancy of the sympathetic ganglia and adrenal glands, hypothesized to originate from progenitors of the developing sympathetic nervous system. Amplification of the MYCN oncogene is a genetic marker of risk in this disease. Understanding the impact of oncogene express...

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Detalles Bibliográficos
Autores principales: Mobley, Bret C., Kwon, Minjae, Kraemer, Bradley R., Hickman, F. Edward, Qiao, Jingbo, Chung, Dai H., Carter, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519318/
https://www.ncbi.nlm.nih.gov/pubmed/26222553
http://dx.doi.org/10.1371/journal.pone.0133897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519318/
https://www.ncbi.nlm.nih.gov/pubmed/26222553
http://dx.doi.org/10.1371/journal.pone.0133897

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