Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

Human aldo-keto reductase 1B15 (AKR1B15) is a newly discovered enzyme which shares 92% amino acid sequence identity with AKR1B10. While AKR1B10 is a well characterized enzyme with high retinaldehyde reductase activity, involved in the development of several cancer types, the enzymatic activity and p...

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Detalles Bibliográficos
Autores principales: Giménez-Dejoz, Joan, Kolář, Michal H., Ruiz, Francesc X., Crespo, Isidro, Cousido-Siah, Alexandra, Podjarny, Alberto, Barski, Oleg A., Fanfrlík, Jindřich, Parés, Xavier, Farrés, Jaume, Porté, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519324/
https://www.ncbi.nlm.nih.gov/pubmed/26222439
http://dx.doi.org/10.1371/journal.pone.0134506

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