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Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity
Photodynamic therapy (PDT) of cancer is an approved therapeutic procedure that generates oxidative stress leading to cell death of tumor and stromal cells. Cell death resulting from oxidative damage to intracellular components leads to the release of damage-associated molecular patterns (DAMPs) that...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519687/ https://www.ncbi.nlm.nih.gov/pubmed/26284197 http://dx.doi.org/10.3389/fonc.2015.00176 |
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author | Wachowska, Malgorzata Muchowicz, Angelika Golab, Jakub |
author_facet | Wachowska, Malgorzata Muchowicz, Angelika Golab, Jakub |
author_sort | Wachowska, Malgorzata |
collection | PubMed |
description | Photodynamic therapy (PDT) of cancer is an approved therapeutic procedure that generates oxidative stress leading to cell death of tumor and stromal cells. Cell death resulting from oxidative damage to intracellular components leads to the release of damage-associated molecular patterns (DAMPs) that trigger robust inflammatory response and creates local conditions for effective sampling of tumor-associated antigens (TAA) by antigen-presenting cells. The latter can trigger development of TAA-specific adaptive immune response. However, due to a number of mechanisms, including epigenetic regulation of TAA expression, tumor cells evade immune recognition. Therefore, numerous approaches are being developed to combine PDT with immunotherapies to allow development of systemic immunity. In this review, we describe immunoregulatory mechanisms of epigenetic treatments that were shown to restore the expression of epigenetically silenced or down-regulated major histocompatibility complex molecules as well as TAA. We also discuss the results of our recent studies showing that epigenetic treatments based on administration of methyltransferase inhibitors in combination with PDT can release effective mechanisms leading to development of antitumor immunity and potentiated antitumor effects. |
format | Online Article Text |
id | pubmed-4519687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45196872015-08-17 Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity Wachowska, Malgorzata Muchowicz, Angelika Golab, Jakub Front Oncol Oncology Photodynamic therapy (PDT) of cancer is an approved therapeutic procedure that generates oxidative stress leading to cell death of tumor and stromal cells. Cell death resulting from oxidative damage to intracellular components leads to the release of damage-associated molecular patterns (DAMPs) that trigger robust inflammatory response and creates local conditions for effective sampling of tumor-associated antigens (TAA) by antigen-presenting cells. The latter can trigger development of TAA-specific adaptive immune response. However, due to a number of mechanisms, including epigenetic regulation of TAA expression, tumor cells evade immune recognition. Therefore, numerous approaches are being developed to combine PDT with immunotherapies to allow development of systemic immunity. In this review, we describe immunoregulatory mechanisms of epigenetic treatments that were shown to restore the expression of epigenetically silenced or down-regulated major histocompatibility complex molecules as well as TAA. We also discuss the results of our recent studies showing that epigenetic treatments based on administration of methyltransferase inhibitors in combination with PDT can release effective mechanisms leading to development of antitumor immunity and potentiated antitumor effects. Frontiers Media S.A. 2015-07-30 /pmc/articles/PMC4519687/ /pubmed/26284197 http://dx.doi.org/10.3389/fonc.2015.00176 Text en Copyright © 2015 Wachowska, Muchowicz and Golab. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wachowska, Malgorzata Muchowicz, Angelika Golab, Jakub Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity |
title | Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity |
title_full | Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity |
title_fullStr | Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity |
title_full_unstemmed | Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity |
title_short | Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity |
title_sort | targeting epigenetic processes in photodynamic therapy-induced anticancer immunity |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519687/ https://www.ncbi.nlm.nih.gov/pubmed/26284197 http://dx.doi.org/10.3389/fonc.2015.00176 |
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