The role of ventral striatal cAMP signaling in stress-induced behaviors

The cAMP/PKA signaling cascade is a ubiquitous pathway acting downstream of multiple neuromodulators. We found that the phosphorylation of phosphodiesterase-4 (PDE4) by cyclin-dependent protein kinase 5 (Cdk5) facilitates cAMP degradation and homeostasis of cAMP/PKA signaling. In mice, loss of Cdk5...

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Detalles Bibliográficos
Autores principales: Plattner, Florian, Hayashi, Kanehiro, Hernandez, Adan, Benavides, David R., Tassin, Tara C., Tan, Chunfeng, Day, Jonathan, Fina, Maggy W., Yuen, Eunice Y., Yan, Zhen, Goldberg, Matthew S., Nairn, Angus C., Greengard, Paul, Nestler, Eric J., Taussig, Ronald, Nishi, Akinori, Houslay, Miles D., Bibb, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519694/
https://www.ncbi.nlm.nih.gov/pubmed/26192746
http://dx.doi.org/10.1038/nn.4066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519694/
https://www.ncbi.nlm.nih.gov/pubmed/26192746
http://dx.doi.org/10.1038/nn.4066

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