Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response

We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT(2C)R) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease i...

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Detalles Bibliográficos
Autores principales: Narzo, Antonio Fabio Di, Kozlenkov, Alexey, Ge, Yongchao, Zhang, Bin, Sanelli, Leo, May, Zacnicte, Li, Yanqing, Fouad, Karim, Cardozo, Christopher, Koonin, Eugene V, Bennett, David J, Dracheva, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519770/
https://www.ncbi.nlm.nih.gov/pubmed/26223940
http://dx.doi.org/10.1038/srep12615

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