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Diabetic Nephropathy without Diabetes
Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519797/ https://www.ncbi.nlm.nih.gov/pubmed/26239683 http://dx.doi.org/10.3390/jcm4071403 |
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author | López-Revuelta, Katia Méndez Abreu, Angel A. Gerrero-Márquez, Carmen Stanescu, Ramona-Ionela Martínez Marín, Maria Isabel Pérez Fernández, Elia |
author_facet | López-Revuelta, Katia Méndez Abreu, Angel A. Gerrero-Márquez, Carmen Stanescu, Ramona-Ionela Martínez Marín, Maria Isabel Pérez Fernández, Elia |
author_sort | López-Revuelta, Katia |
collection | PubMed |
description | Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except one series of attached data. DNND appears to be favored by recognized cardiovascular risk factors. However, in contrast with diabetes, apparently no factor alone has been demonstrated to be sufficient to develop DNND. Other factors not considered as genetic and environmental factors could play a role or interact. The most plausible hypothesis for the occurrence of DNND would be a special form of atherosclerotic or metabolic glomerulopathy than can occur with or without diabetes. The clinical spectrum of cardiovascular risk factors and histological findings support this theory, with hypertension as one of the characteristic clinical features. |
format | Online Article Text |
id | pubmed-4519797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45197972015-07-30 Diabetic Nephropathy without Diabetes López-Revuelta, Katia Méndez Abreu, Angel A. Gerrero-Márquez, Carmen Stanescu, Ramona-Ionela Martínez Marín, Maria Isabel Pérez Fernández, Elia J Clin Med Review Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except one series of attached data. DNND appears to be favored by recognized cardiovascular risk factors. However, in contrast with diabetes, apparently no factor alone has been demonstrated to be sufficient to develop DNND. Other factors not considered as genetic and environmental factors could play a role or interact. The most plausible hypothesis for the occurrence of DNND would be a special form of atherosclerotic or metabolic glomerulopathy than can occur with or without diabetes. The clinical spectrum of cardiovascular risk factors and histological findings support this theory, with hypertension as one of the characteristic clinical features. MDPI 2015-07-09 /pmc/articles/PMC4519797/ /pubmed/26239683 http://dx.doi.org/10.3390/jcm4071403 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review López-Revuelta, Katia Méndez Abreu, Angel A. Gerrero-Márquez, Carmen Stanescu, Ramona-Ionela Martínez Marín, Maria Isabel Pérez Fernández, Elia Diabetic Nephropathy without Diabetes |
title | Diabetic Nephropathy without Diabetes |
title_full | Diabetic Nephropathy without Diabetes |
title_fullStr | Diabetic Nephropathy without Diabetes |
title_full_unstemmed | Diabetic Nephropathy without Diabetes |
title_short | Diabetic Nephropathy without Diabetes |
title_sort | diabetic nephropathy without diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519797/ https://www.ncbi.nlm.nih.gov/pubmed/26239683 http://dx.doi.org/10.3390/jcm4071403 |
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