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Effect of pH on the Aggregation of α-syn12 Dimer in Explicit Water by Replica-Exchange Molecular Dynamics Simulation

The dimeric structure of the N-terminal 12 residues drives the interaction of α-synuclein protein with membranes. Moreover, experimental studies indicated that the aggregation of α-synuclein is faster at low pH than neutral pH. Nevertheless, the effects of different pH on the structural characterist...

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Detalles Bibliográficos
Autores principales:	Cao, Zanxia, Zhang, Xiumei, Liu, Lei, Zhao, Liling, Li, Haiyan, Wang, Jihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519842/ https://www.ncbi.nlm.nih.gov/pubmed/26114384 http://dx.doi.org/10.3390/ijms160714291

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