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Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity

Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN...

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Autores principales: Sun, Kexin, Xiang, Xiao, Li, Na, Huang, Shaoping, Qin, Xueying, Wu, Yiqun, Tang, Xun, Gao, Pei, Li, Jing, Wu, Tao, Chen, Dafang, Hu, Yonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519845/
https://www.ncbi.nlm.nih.gov/pubmed/26114387
http://dx.doi.org/10.3390/ijms160714338
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author Sun, Kexin
Xiang, Xiao
Li, Na
Huang, Shaoping
Qin, Xueying
Wu, Yiqun
Tang, Xun
Gao, Pei
Li, Jing
Wu, Tao
Chen, Dafang
Hu, Yonghua
author_facet Sun, Kexin
Xiang, Xiao
Li, Na
Huang, Shaoping
Qin, Xueying
Wu, Yiqun
Tang, Xun
Gao, Pei
Li, Jing
Wu, Tao
Chen, Dafang
Hu, Yonghua
author_sort Sun, Kexin
collection PubMed
description Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤100 vs. >100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found.
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spelling pubmed-45198452015-08-03 Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity Sun, Kexin Xiang, Xiao Li, Na Huang, Shaoping Qin, Xueying Wu, Yiqun Tang, Xun Gao, Pei Li, Jing Wu, Tao Chen, Dafang Hu, Yonghua Int J Mol Sci Article Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤100 vs. >100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found. MDPI 2015-06-24 /pmc/articles/PMC4519845/ /pubmed/26114387 http://dx.doi.org/10.3390/ijms160714338 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Kexin
Xiang, Xiao
Li, Na
Huang, Shaoping
Qin, Xueying
Wu, Yiqun
Tang, Xun
Gao, Pei
Li, Jing
Wu, Tao
Chen, Dafang
Hu, Yonghua
Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
title Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
title_full Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
title_fullStr Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
title_full_unstemmed Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
title_short Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
title_sort gene-diet interaction between sirt6 and soybean intake for different levels of pulse wave velocity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519845/
https://www.ncbi.nlm.nih.gov/pubmed/26114387
http://dx.doi.org/10.3390/ijms160714338
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