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Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity
Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519845/ https://www.ncbi.nlm.nih.gov/pubmed/26114387 http://dx.doi.org/10.3390/ijms160714338 |
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author | Sun, Kexin Xiang, Xiao Li, Na Huang, Shaoping Qin, Xueying Wu, Yiqun Tang, Xun Gao, Pei Li, Jing Wu, Tao Chen, Dafang Hu, Yonghua |
author_facet | Sun, Kexin Xiang, Xiao Li, Na Huang, Shaoping Qin, Xueying Wu, Yiqun Tang, Xun Gao, Pei Li, Jing Wu, Tao Chen, Dafang Hu, Yonghua |
author_sort | Sun, Kexin |
collection | PubMed |
description | Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤100 vs. >100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found. |
format | Online Article Text |
id | pubmed-4519845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45198452015-08-03 Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity Sun, Kexin Xiang, Xiao Li, Na Huang, Shaoping Qin, Xueying Wu, Yiqun Tang, Xun Gao, Pei Li, Jing Wu, Tao Chen, Dafang Hu, Yonghua Int J Mol Sci Article Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤100 vs. >100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found. MDPI 2015-06-24 /pmc/articles/PMC4519845/ /pubmed/26114387 http://dx.doi.org/10.3390/ijms160714338 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Kexin Xiang, Xiao Li, Na Huang, Shaoping Qin, Xueying Wu, Yiqun Tang, Xun Gao, Pei Li, Jing Wu, Tao Chen, Dafang Hu, Yonghua Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity |
title | Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity |
title_full | Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity |
title_fullStr | Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity |
title_full_unstemmed | Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity |
title_short | Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity |
title_sort | gene-diet interaction between sirt6 and soybean intake for different levels of pulse wave velocity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519845/ https://www.ncbi.nlm.nih.gov/pubmed/26114387 http://dx.doi.org/10.3390/ijms160714338 |
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