Cargando…

Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis

Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replic...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Bo-Hua, Tseng, Wei-Lien, Li, Hsin-Yang, Wang, Mong-Lien, Chang, Yuh-Lih, Sung, Yen-Jen, Chiou, Shih-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519911/
https://www.ncbi.nlm.nih.gov/pubmed/26184161
http://dx.doi.org/10.3390/ijms160715531
_version_ 1782383577033342976
author Jiang, Bo-Hua
Tseng, Wei-Lien
Li, Hsin-Yang
Wang, Mong-Lien
Chang, Yuh-Lih
Sung, Yen-Jen
Chiou, Shih-Hwa
author_facet Jiang, Bo-Hua
Tseng, Wei-Lien
Li, Hsin-Yang
Wang, Mong-Lien
Chang, Yuh-Lih
Sung, Yen-Jen
Chiou, Shih-Hwa
author_sort Jiang, Bo-Hua
collection PubMed
description Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin remodeling through PARylation of downstream proteins. In addition, high expression level and activity of Parp1 are correlated with pluripotent status, reprogramming, and cancer. Furthermore, epigenetic modulation of Parp1 is explored for regulating wide variety of gene expression. Genetic and pharmaceutical disruption of Parp1 further confirmed the importance of Parp1 in cell growth, DNA repair, and reprogramming efficiency. Taken together, the proximity toward the understanding of the modulation of Parp1 including interaction and modification in different fields will provide new insight for future studies. In this review, the biological significance of Parp1 in transcription and the epigenetic modulation of Parp1 in pluripotent status, reprogramming process and cancer will be summarized.
format Online
Article
Text
id pubmed-4519911
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-45199112015-08-03 Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis Jiang, Bo-Hua Tseng, Wei-Lien Li, Hsin-Yang Wang, Mong-Lien Chang, Yuh-Lih Sung, Yen-Jen Chiou, Shih-Hwa Int J Mol Sci Review Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin remodeling through PARylation of downstream proteins. In addition, high expression level and activity of Parp1 are correlated with pluripotent status, reprogramming, and cancer. Furthermore, epigenetic modulation of Parp1 is explored for regulating wide variety of gene expression. Genetic and pharmaceutical disruption of Parp1 further confirmed the importance of Parp1 in cell growth, DNA repair, and reprogramming efficiency. Taken together, the proximity toward the understanding of the modulation of Parp1 including interaction and modification in different fields will provide new insight for future studies. In this review, the biological significance of Parp1 in transcription and the epigenetic modulation of Parp1 in pluripotent status, reprogramming process and cancer will be summarized. MDPI 2015-07-09 /pmc/articles/PMC4519911/ /pubmed/26184161 http://dx.doi.org/10.3390/ijms160715531 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Bo-Hua
Tseng, Wei-Lien
Li, Hsin-Yang
Wang, Mong-Lien
Chang, Yuh-Lih
Sung, Yen-Jen
Chiou, Shih-Hwa
Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
title Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
title_full Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
title_fullStr Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
title_full_unstemmed Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
title_short Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
title_sort poly(adp-ribose) polymerase 1: cellular pluripotency, reprogramming, and tumorogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519911/
https://www.ncbi.nlm.nih.gov/pubmed/26184161
http://dx.doi.org/10.3390/ijms160715531
work_keys_str_mv AT jiangbohua polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis
AT tsengweilien polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis
AT lihsinyang polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis
AT wangmonglien polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis
AT changyuhlih polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis
AT sungyenjen polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis
AT chioushihhwa polyadpribosepolymerase1cellularpluripotencyreprogrammingandtumorogenesis