Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor

Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity. We previously found that baicalin had t...

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Detalles Bibliográficos
Autores principales: Wang, Ke, Feng, Chenchen, Li, Chenggang, Yao, Jun, Xie, Xiaofeng, Gong, Likun, Luan, Yang, Xing, Guozhen, Zhu, Xue, Qi, Xinming, Ren, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519959/
https://www.ncbi.nlm.nih.gov/pubmed/26204831
http://dx.doi.org/10.3390/ijms160716454

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