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What Do We Know about the Role of miRNAs in Pediatric Sarcoma?
Non-coding RNAs have received a lot of attention in recent years, with especial focus on microRNAs (miRNAs), so much so that in the just over two decades since the first miRNA, Lin4, was described, almost 40,000 publications about miRNAs have been generated. Less than 500 of these focus on sarcoma,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519968/ https://www.ncbi.nlm.nih.gov/pubmed/26204834 http://dx.doi.org/10.3390/ijms160716593 |
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author | Kelly, Lorna C. Lázaro, Antonio O’Sullivan, Maureen J. |
author_facet | Kelly, Lorna C. Lázaro, Antonio O’Sullivan, Maureen J. |
author_sort | Kelly, Lorna C. |
collection | PubMed |
description | Non-coding RNAs have received a lot of attention in recent years, with especial focus on microRNAs (miRNAs), so much so that in the just over two decades since the first miRNA, Lin4, was described, almost 40,000 publications about miRNAs have been generated. Less than 500 of these focus on sarcoma, and only a fraction of those on sarcomas of childhood specifically, with some of these representing observational studies and others containing functionally validated data. This is a group of cancers for which prognosis is often poor and therapeutic options limited, and it is especially in these areas that strides in understanding the role of non-coding RNAs and miRNAs in particular are to be welcomed. This review deals with the main forms of pediatric sarcoma, exploring what is known about the diagnostic and prognostic profiles of miRNAs in these tumours and where novel therapeutic options might present themselves for further exploration. |
format | Online Article Text |
id | pubmed-4519968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45199682015-08-03 What Do We Know about the Role of miRNAs in Pediatric Sarcoma? Kelly, Lorna C. Lázaro, Antonio O’Sullivan, Maureen J. Int J Mol Sci Review Non-coding RNAs have received a lot of attention in recent years, with especial focus on microRNAs (miRNAs), so much so that in the just over two decades since the first miRNA, Lin4, was described, almost 40,000 publications about miRNAs have been generated. Less than 500 of these focus on sarcoma, and only a fraction of those on sarcomas of childhood specifically, with some of these representing observational studies and others containing functionally validated data. This is a group of cancers for which prognosis is often poor and therapeutic options limited, and it is especially in these areas that strides in understanding the role of non-coding RNAs and miRNAs in particular are to be welcomed. This review deals with the main forms of pediatric sarcoma, exploring what is known about the diagnostic and prognostic profiles of miRNAs in these tumours and where novel therapeutic options might present themselves for further exploration. MDPI 2015-07-22 /pmc/articles/PMC4519968/ /pubmed/26204834 http://dx.doi.org/10.3390/ijms160716593 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kelly, Lorna C. Lázaro, Antonio O’Sullivan, Maureen J. What Do We Know about the Role of miRNAs in Pediatric Sarcoma? |
title | What Do We Know about the Role of miRNAs in Pediatric Sarcoma? |
title_full | What Do We Know about the Role of miRNAs in Pediatric Sarcoma? |
title_fullStr | What Do We Know about the Role of miRNAs in Pediatric Sarcoma? |
title_full_unstemmed | What Do We Know about the Role of miRNAs in Pediatric Sarcoma? |
title_short | What Do We Know about the Role of miRNAs in Pediatric Sarcoma? |
title_sort | what do we know about the role of mirnas in pediatric sarcoma? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519968/ https://www.ncbi.nlm.nih.gov/pubmed/26204834 http://dx.doi.org/10.3390/ijms160716593 |
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