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Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer

BACKGROUND: Pro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apoptotic Bcl-2 family members. Increased levels of these anti-apoptotic proteins h...

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Detalles Bibliográficos
Autores principales:	Zerp, Shuraila F., Stoter, T. Rianne, Hoebers, Frank J. P., van den Brekel, Michiel W. M., Dubbelman, Ria, Kuipers, Gitta K., Lafleur, M. Vincent M., Slotman, Ben J., Verheij, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520130/ https://www.ncbi.nlm.nih.gov/pubmed/26223311 http://dx.doi.org/10.1186/s13014-015-0474-9

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