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Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report

BACKGROUND: Central nervous system bleeding is a rare complication of neurosarcoidosis: only 18 cases of spontaneous cerebral hematoma have been reported. We present the first recorded case of spinal cord hemorrhage in neurosarcoidosis. CASE PRESENTATION: A 48-year-old Caucasian woman had relapsing...

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Autores principales: Pegat, Benoit, Drapier, Sophie, Morandi, Xavier, Edan, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520197/
https://www.ncbi.nlm.nih.gov/pubmed/26224095
http://dx.doi.org/10.1186/s12883-015-0373-6
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author Pegat, Benoit
Drapier, Sophie
Morandi, Xavier
Edan, Gilles
author_facet Pegat, Benoit
Drapier, Sophie
Morandi, Xavier
Edan, Gilles
author_sort Pegat, Benoit
collection PubMed
description BACKGROUND: Central nervous system bleeding is a rare complication of neurosarcoidosis: only 18 cases of spontaneous cerebral hematoma have been reported. We present the first recorded case of spinal cord hemorrhage in neurosarcoidosis. CASE PRESENTATION: A 48-year-old Caucasian woman had relapsing neurosarcoidosis for 5 years, with inflammatory spinal and cerebral lesions. While on 20 mg corticosteroids, she experienced subacute paraparesia with right leg pain. A spine MRI revealed a low thoracic hematomyelia at the T10-T11 level. Despite high doses of corticosteroids, her condition continued to worsen. Surgical evacuation of the hematoma was performed 10 days after the onset of bleeding, and she partially recovered. CONCLUSION: This report highlights the possibility of spinal cord hemorrhage secondary to sarcoid vasculitis. The patient improved after surgical evacuation of the intramedullary hematoma. Immuno-modulating agents must be envisaged in severe neurosarcoidosis, to prevent complications.
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spelling pubmed-45201972015-07-31 Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report Pegat, Benoit Drapier, Sophie Morandi, Xavier Edan, Gilles BMC Neurol Case Report BACKGROUND: Central nervous system bleeding is a rare complication of neurosarcoidosis: only 18 cases of spontaneous cerebral hematoma have been reported. We present the first recorded case of spinal cord hemorrhage in neurosarcoidosis. CASE PRESENTATION: A 48-year-old Caucasian woman had relapsing neurosarcoidosis for 5 years, with inflammatory spinal and cerebral lesions. While on 20 mg corticosteroids, she experienced subacute paraparesia with right leg pain. A spine MRI revealed a low thoracic hematomyelia at the T10-T11 level. Despite high doses of corticosteroids, her condition continued to worsen. Surgical evacuation of the hematoma was performed 10 days after the onset of bleeding, and she partially recovered. CONCLUSION: This report highlights the possibility of spinal cord hemorrhage secondary to sarcoid vasculitis. The patient improved after surgical evacuation of the intramedullary hematoma. Immuno-modulating agents must be envisaged in severe neurosarcoidosis, to prevent complications. BioMed Central 2015-07-30 /pmc/articles/PMC4520197/ /pubmed/26224095 http://dx.doi.org/10.1186/s12883-015-0373-6 Text en © Pegat et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Pegat, Benoit
Drapier, Sophie
Morandi, Xavier
Edan, Gilles
Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
title Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
title_full Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
title_fullStr Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
title_full_unstemmed Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
title_short Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
title_sort spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520197/
https://www.ncbi.nlm.nih.gov/pubmed/26224095
http://dx.doi.org/10.1186/s12883-015-0373-6
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