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The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies

We herein present the National NeuroAIDS Tissue Consortium-Data Coordinating Center (NNTC-DCC) database, which is the only available database for neuroAIDS studies that contains data in an integrated, standardized form. This database has been created in conjunction with the NNTC, which provides huma...

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Autores principales: Cserhati, Matyas F., Pandey, Sanjit, Beaudoin, James J., Baccaglini, Lorena, Guda, Chittibabu, Fox, Howard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520230/
https://www.ncbi.nlm.nih.gov/pubmed/26228431
http://dx.doi.org/10.1093/database/bav074
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author Cserhati, Matyas F.
Pandey, Sanjit
Beaudoin, James J.
Baccaglini, Lorena
Guda, Chittibabu
Fox, Howard S.
author_facet Cserhati, Matyas F.
Pandey, Sanjit
Beaudoin, James J.
Baccaglini, Lorena
Guda, Chittibabu
Fox, Howard S.
author_sort Cserhati, Matyas F.
collection PubMed
description We herein present the National NeuroAIDS Tissue Consortium-Data Coordinating Center (NNTC-DCC) database, which is the only available database for neuroAIDS studies that contains data in an integrated, standardized form. This database has been created in conjunction with the NNTC, which provides human tissue and biofluid samples to individual researchers to conduct studies focused on neuroAIDS. The database contains experimental datasets from 1206 subjects for the following categories (which are further broken down into subcategories): gene expression, genotype, proteins, endo-exo-chemicals, morphometrics and other (miscellaneous) data. The database also contains a wide variety of downloadable data and metadata for 95 HIV-related studies covering 170 assays from 61 principal investigators. The data represent 76 tissue types, 25 measurement types, and 38 technology types, and reaches a total of 33 017 407 data points. We used the ISA platform to create the database and develop a searchable web interface for querying the data. A gene search tool is also available, which searches for NCBI GEO datasets associated with selected genes. The database is manually curated with many user-friendly features, and is cross-linked to the NCBI, HUGO and PubMed databases. A free registration is required for qualified users to access the database. Database URL: http://nntc-dcc.unmc.edu
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spelling pubmed-45202302015-08-04 The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies Cserhati, Matyas F. Pandey, Sanjit Beaudoin, James J. Baccaglini, Lorena Guda, Chittibabu Fox, Howard S. Database (Oxford) Original Article We herein present the National NeuroAIDS Tissue Consortium-Data Coordinating Center (NNTC-DCC) database, which is the only available database for neuroAIDS studies that contains data in an integrated, standardized form. This database has been created in conjunction with the NNTC, which provides human tissue and biofluid samples to individual researchers to conduct studies focused on neuroAIDS. The database contains experimental datasets from 1206 subjects for the following categories (which are further broken down into subcategories): gene expression, genotype, proteins, endo-exo-chemicals, morphometrics and other (miscellaneous) data. The database also contains a wide variety of downloadable data and metadata for 95 HIV-related studies covering 170 assays from 61 principal investigators. The data represent 76 tissue types, 25 measurement types, and 38 technology types, and reaches a total of 33 017 407 data points. We used the ISA platform to create the database and develop a searchable web interface for querying the data. A gene search tool is also available, which searches for NCBI GEO datasets associated with selected genes. The database is manually curated with many user-friendly features, and is cross-linked to the NCBI, HUGO and PubMed databases. A free registration is required for qualified users to access the database. Database URL: http://nntc-dcc.unmc.edu Oxford University Press 2015-07-30 /pmc/articles/PMC4520230/ /pubmed/26228431 http://dx.doi.org/10.1093/database/bav074 Text en © The Author(s) 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cserhati, Matyas F.
Pandey, Sanjit
Beaudoin, James J.
Baccaglini, Lorena
Guda, Chittibabu
Fox, Howard S.
The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies
title The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies
title_full The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies
title_fullStr The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies
title_full_unstemmed The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies
title_short The National NeuroAIDS Tissue Consortium (NNTC) Database: an integrated database for HIV-related studies
title_sort national neuroaids tissue consortium (nntc) database: an integrated database for hiv-related studies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520230/
https://www.ncbi.nlm.nih.gov/pubmed/26228431
http://dx.doi.org/10.1093/database/bav074
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