Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

Sensory neurons expressing Mas-related G protein coupled receptors (Mrgprs) mediate histamine-independent itch. We show that the cysteine protease cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice. In contrast to its activation of conventional protease-activated recepto...

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Detalles Bibliográficos
Autores principales: Reddy, Vemuri B., Sun, Shuohao, Azimi, Ehsan, Elmariah, Sarina B., Dong, Xinzhong, Lerner, Ethan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520244/
https://www.ncbi.nlm.nih.gov/pubmed/26216096
http://dx.doi.org/10.1038/ncomms8864

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