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Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography

OBJECTIVE: Menopause is a physiological life period that potentially affects various organs and systems. Therefore, a wide spectrum of signs and symptoms of eyes may be clinically observed in the postmenopausal period. AIM OF THE STUDY: To evaluate the macular, retinal nerve fiber layer (RNFL) and c...

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Autores principales: Ataş, Mustafa, Açmaz, Gökhan, Aksoy, Hüseyin, Demircan, Süleyman, Göktaş, Altan, Arifoğlu, Hasan Basri, Zararsız, Gökmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520339/
https://www.ncbi.nlm.nih.gov/pubmed/26327827
http://dx.doi.org/10.5114/pm.2014.41088
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author Ataş, Mustafa
Açmaz, Gökhan
Aksoy, Hüseyin
Demircan, Süleyman
Göktaş, Altan
Arifoğlu, Hasan Basri
Zararsız, Gökmen
author_facet Ataş, Mustafa
Açmaz, Gökhan
Aksoy, Hüseyin
Demircan, Süleyman
Göktaş, Altan
Arifoğlu, Hasan Basri
Zararsız, Gökmen
author_sort Ataş, Mustafa
collection PubMed
description OBJECTIVE: Menopause is a physiological life period that potentially affects various organs and systems. Therefore, a wide spectrum of signs and symptoms of eyes may be clinically observed in the postmenopausal period. AIM OF THE STUDY: To evaluate the macular, retinal nerve fiber layer (RNFL) and choroidal thickness alterations by using spectral-domain optical coherence tomography (SD-OCT) in postmenopausal women and compare with healthy reproductive-age women controls. MATERIAL AND METHODS: The study population included a healthy reproductive-age control group (n = 72) and postmenopausal study group (n = 72). Retinal thickness parameters were measured by SD-OCT. Peripapillary RNFL thickness parameters, macular thickness and choroidal thickness were evaluated. RESULTS: Superior inner macula, temporal inner macula, inferior inner macula, nasal inner macula, inferior outer macula and choroid thickness were significantly thinner in the postmenopausal study group than the healthy reproductive-age control group (p = 0.007, p = 0.037, p = 0.027, p = 0.006, p = 0.016, p < 0.001, respectively). After adjusting for age, only choroid thickness was significantly thinner in the postmenopausal study group than controls (p (†) = 0.005). CONCLUSIONS: This study revealed that choroidal thickness measured by SD-OCT was significantly thinner in postmenopausal women than healthy reproductive-age women. We can speculate that the decrease in choroidal thickness in postmenopausal women may indicate a reduced estrogen-dependent vasodilatory effect in ophthalmic artery secondary to menopausal estrogen deficiency.
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spelling pubmed-45203392015-08-31 Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography Ataş, Mustafa Açmaz, Gökhan Aksoy, Hüseyin Demircan, Süleyman Göktaş, Altan Arifoğlu, Hasan Basri Zararsız, Gökmen Prz Menopauzalny Original Paper OBJECTIVE: Menopause is a physiological life period that potentially affects various organs and systems. Therefore, a wide spectrum of signs and symptoms of eyes may be clinically observed in the postmenopausal period. AIM OF THE STUDY: To evaluate the macular, retinal nerve fiber layer (RNFL) and choroidal thickness alterations by using spectral-domain optical coherence tomography (SD-OCT) in postmenopausal women and compare with healthy reproductive-age women controls. MATERIAL AND METHODS: The study population included a healthy reproductive-age control group (n = 72) and postmenopausal study group (n = 72). Retinal thickness parameters were measured by SD-OCT. Peripapillary RNFL thickness parameters, macular thickness and choroidal thickness were evaluated. RESULTS: Superior inner macula, temporal inner macula, inferior inner macula, nasal inner macula, inferior outer macula and choroid thickness were significantly thinner in the postmenopausal study group than the healthy reproductive-age control group (p = 0.007, p = 0.037, p = 0.027, p = 0.006, p = 0.016, p < 0.001, respectively). After adjusting for age, only choroid thickness was significantly thinner in the postmenopausal study group than controls (p (†) = 0.005). CONCLUSIONS: This study revealed that choroidal thickness measured by SD-OCT was significantly thinner in postmenopausal women than healthy reproductive-age women. We can speculate that the decrease in choroidal thickness in postmenopausal women may indicate a reduced estrogen-dependent vasodilatory effect in ophthalmic artery secondary to menopausal estrogen deficiency. Termedia Publishing House 2014-03-10 2014-03 /pmc/articles/PMC4520339/ /pubmed/26327827 http://dx.doi.org/10.5114/pm.2014.41088 Text en Copyright © 2014 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Ataş, Mustafa
Açmaz, Gökhan
Aksoy, Hüseyin
Demircan, Süleyman
Göktaş, Altan
Arifoğlu, Hasan Basri
Zararsız, Gökmen
Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
title Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
title_full Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
title_fullStr Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
title_full_unstemmed Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
title_short Evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
title_sort evaluation of the macula, retinal nerve fiber layer and choroid thickness in postmenopausal women and reproductive-age women using spectral-domain optical coherence tomography
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520339/
https://www.ncbi.nlm.nih.gov/pubmed/26327827
http://dx.doi.org/10.5114/pm.2014.41088
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