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The role of angiogenic factors in endometrial cancer
Endometrial cancer is the most common malignancy within the female reproductive system (37.7%). The incidence increases with age. Frequently this type of cancer is diagnosed in peri- and post-menopausal women. 60-70% of cancers occur in women over 60 years of age, and less than 5% in women below 40...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520350/ https://www.ncbi.nlm.nih.gov/pubmed/26327841 http://dx.doi.org/10.5114/pm.2014.42714 |
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author | Żyła, Monika Magdalena Kostrzewa, Marta Litwińska, Ewelina Szpakowski, Artur Wilczyński, Jacek Radosław Stetkiewicz, Tomasz |
author_facet | Żyła, Monika Magdalena Kostrzewa, Marta Litwińska, Ewelina Szpakowski, Artur Wilczyński, Jacek Radosław Stetkiewicz, Tomasz |
author_sort | Żyła, Monika Magdalena |
collection | PubMed |
description | Endometrial cancer is the most common malignancy within the female reproductive system (37.7%). The incidence increases with age. Frequently this type of cancer is diagnosed in peri- and post-menopausal women. 60-70% of cancers occur in women over 60 years of age, and less than 5% in women below 40 years of age. Angiogenesis is a process of formation of new microvessels from existing capillaries. There are four different mechanisms of new vessel growth: sprouting, intussusception, vessel elongation and incorporation of endothelial progenitor cells into new microvessels. Angiogenesis plays important roles in growth of endometrial cancers. This process is controlled by many angiogenic factors, for example vascular endothelial growth factor (VEGF). VEGF is the most powerful and most specific endothelial cell growth factor. It plays a crucial role in the initiation of physiological and pathological angiogenesis, lymphangiogenesis, and vasculogenesis. The VEGF family consists of VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and PLGF (placental growth factor). The effects of VEGF are mediated through binding to the two specific and homologous receptors VEGFR-1 (FLT-1) and VEGFR-2 (KDR). Placental growth factor (PLGF) belongs to the VEGF family and it is also a very important growth factor. So far four isoforms of PLGF have been identified: PLGF-1 (PLGF131), PLGF-2 (PLGF152), PLGF-3 (PLGF203) and PLGF-4 (PLGF224). |
format | Online Article Text |
id | pubmed-4520350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-45203502015-08-31 The role of angiogenic factors in endometrial cancer Żyła, Monika Magdalena Kostrzewa, Marta Litwińska, Ewelina Szpakowski, Artur Wilczyński, Jacek Radosław Stetkiewicz, Tomasz Prz Menopauzalny Review Paper Endometrial cancer is the most common malignancy within the female reproductive system (37.7%). The incidence increases with age. Frequently this type of cancer is diagnosed in peri- and post-menopausal women. 60-70% of cancers occur in women over 60 years of age, and less than 5% in women below 40 years of age. Angiogenesis is a process of formation of new microvessels from existing capillaries. There are four different mechanisms of new vessel growth: sprouting, intussusception, vessel elongation and incorporation of endothelial progenitor cells into new microvessels. Angiogenesis plays important roles in growth of endometrial cancers. This process is controlled by many angiogenic factors, for example vascular endothelial growth factor (VEGF). VEGF is the most powerful and most specific endothelial cell growth factor. It plays a crucial role in the initiation of physiological and pathological angiogenesis, lymphangiogenesis, and vasculogenesis. The VEGF family consists of VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and PLGF (placental growth factor). The effects of VEGF are mediated through binding to the two specific and homologous receptors VEGFR-1 (FLT-1) and VEGFR-2 (KDR). Placental growth factor (PLGF) belongs to the VEGF family and it is also a very important growth factor. So far four isoforms of PLGF have been identified: PLGF-1 (PLGF131), PLGF-2 (PLGF152), PLGF-3 (PLGF203) and PLGF-4 (PLGF224). Termedia Publishing House 2014-05-21 2014-05 /pmc/articles/PMC4520350/ /pubmed/26327841 http://dx.doi.org/10.5114/pm.2014.42714 Text en Copyright © 2014 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Paper Żyła, Monika Magdalena Kostrzewa, Marta Litwińska, Ewelina Szpakowski, Artur Wilczyński, Jacek Radosław Stetkiewicz, Tomasz The role of angiogenic factors in endometrial cancer |
title | The role of angiogenic factors in endometrial cancer |
title_full | The role of angiogenic factors in endometrial cancer |
title_fullStr | The role of angiogenic factors in endometrial cancer |
title_full_unstemmed | The role of angiogenic factors in endometrial cancer |
title_short | The role of angiogenic factors in endometrial cancer |
title_sort | role of angiogenic factors in endometrial cancer |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520350/ https://www.ncbi.nlm.nih.gov/pubmed/26327841 http://dx.doi.org/10.5114/pm.2014.42714 |
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